CCNE1

CCNE1

A gene on chromosome 19q12 that encodes cyclin E1, which forms a complex with and acts as a regulatory subunit of CDK2. Cyclin E1 is required for cell cycle G1/S (start) transition; it accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. It is highly expressed in the testes and placenta.
Mentioned in ?
References in periodicals archive ?
NGS identified genomic aberrations in AKT2, TP53, CCNE1, MYC, MCL1, and AXL.
Statistical methods have been used to define a number of genomic regions of significant copy number alteration in serous-like tumors, including regions of focal amplification involving the MYC (v-myc avian myelocytomatosis viral oncogene homolog) oncogene, the ERBB2 (HER2) receptor tyrosine kinase gene, and CCNE1 (cyclin E1), which are each focally amplified in 23%-25% of cases (15).
Many genes whose expression is regulated by E2F family transcription factors, including CDK2, CCNE1, CDC6, CDC2, MCM2, were significantly down-regulated at 24 hr post-IR.
CCNE1 and v-myb myeloblastosis viral oncogene homolog avian-like 2 (MFBL2) are important genes involved in the [G.