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NGS identified genomic aberrations in AKT2, TP53, CCNE1, MYC, MCL1, and AXL.
Statistical methods have been used to define a number of genomic regions of significant copy number alteration in serous-like tumors, including regions of focal amplification involving the MYC (v-myc avian myelocytomatosis viral oncogene homolog) oncogene, the ERBB2 (HER2) receptor tyrosine kinase gene, and CCNE1 (cyclin E1), which are each focally amplified in 23%-25% of cases (15).
Many genes whose expression is regulated by E2F family transcription factors, including CDK2, CCNE1, CDC6, CDC2, MCM2, were significantly down-regulated at 24 hr post-IR.
CCNE1 and v-myb myeloblastosis viral oncogene homolog avian-like 2 (MFBL2) are important genes involved in the [G.
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