CCND3

CCND3

A gene on chromosome 6p21 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D3 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition. It also interacts with tumour suppressor protein Rb and is involved in its phosphorylation. The cyclin D3-CDK4 complex is involved in cell cycle progression through G2 phase into mitosis after UV light-induced damage.
References in periodicals archive ?
These rearrangements can involve more than a dozen partners, including CCND1-XT (chromosome 11), FGFR3 (chromosome 4), MAF (chromosome 16), CCND3 (chromosome 6), and MAFB (chromosome 20), as well as unknown partners.
Researchers were able to demonstrate that the enzymatic activity of PFTK1 was dependent upon CCND3 and was negatively regulated by p21.
They found CCND3 expression to be highly sensitive and specific for recurrence (97% and 63%, respectively).