CCND2

CCND2

A gene on chromosome 12p13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D2 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it is thought to play a central role in germ cell proliferation. Cyclin D2 interacts with tumour suppressor protein Rb and is involved in its phosphorylation.

Molecular pathology
CCND2 is overexpressed in ovarian and testicular tumours.
References in periodicals archive ?
In our network, miR-139 targets ETS1, TCF4, ZEB1, and CCND2.
It promotes tumorigenicity by repressing stemnessinhibiting miRNAs); CCND2, cyclin D2 (cyclin D2 forms a complex with and regulates CDK4 and CDK6 in cell cycle G1/S transition.
CCND2 - a gene involved in cell-cycle control, which is a key control mechanism to prevent cancer development
III] specific E-cadherin CDH1 Cell-cell adhesion CDC2-related protein CRK7 Protein kinase activity kinase 7 Tubulin-specific TBCD Beta-tubulin folding chaperone d Cisplatin resistance CRR9 Integral to membrane related protein CRR9p Cyclin D2 CCND2 Regulation of cell cycle Polymerase IDNA directed), POLB DNA replication beta Ring finger protein 141 RNF141 Ubiquitin ligase complex Nuclear factor of NFATC2 Transcription factor activated T-cells, activity cytoplasmic, calcineurin-dependent 2 S100 calcium binding S100P Calcium ion binding protein P Fem-1 homolog c FEM1C Unknown (C.
The genes most predictive of overall survival in DLBCL were LMO2, BCL6, FN1, CCND2, SCYA3 and BCL2.
Subsequent work revealed that let-7 regulates a number of other oncogenes, including CCND2 (cyclin D2), CDK6 (cyclin-dependent kinase 6), CDC25 [cell division cycle 25 homolog C (S.
For example, one risk variant is located near CCND2, the gene encoding cyclin D2, a member of the cyclin family of proteins that regulate the cell cycle.
43) Methylation of TSG loci APC, CCND2, CDKN2A, CDKN2B, HPPBP1, and RASSF1 was studied in comparison with asbestos exposure.
For example, LD extends across the 283-kb NF1, whereas fewer correlated sites are present in the smaller CCND2.
Other cancer-related genes that have been shown to undergo abnormal methylation and induced gene silencing include RELN, (112) CCND2, (105) TFPI2, (113) RUNX3, (114) SOCS 1, (115) and TSLC1/IGSF4.