CCND1


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CCND1

A gene on chromosome 11q13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D1 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it also interacts with tumour suppressor protein Rb, which regulates the expression of CCND1.
 
Molecular pathology
CCND1 mutations, amplification and overexpression alter cell cycle progression, occur in various tumours and play a role in tumourigenesis.
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10] exposure attenuates age-related lung function decline: genetic variants in p53, p27, and CCND1 modify this effect.
The power of our flow-sorting work flow for high-resolution profiling was exemplified by the direct identification of CCND1 as a frequently amplified gene in our study cohort.
The most common clinically relevant GAs were KRAS (16%), CDKN2A (14%), CCND1 (9.
Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk.
The study found that AHR interacts with other signaling molecules in the cell, CDK4 and CCND1, which could affect the regulation of cell division.
The study of molecular alterations has successfully elucidated some mechanisms of mammary oncogenesis and identified key genes such as oestrogen receptor (ER), epidermal growth factor receptor 2 (ERBB2/HER2), TP53, CCND1 and BRCA1.
Casson showed that the CCND1 G870A polymorphism is found with increasing frequency through the chronic inflammation spectrum, from gastroesophageal reflux disease (GERD) through Barrett's esophagus (BE) and on to esophageal adenocarcinoma (EACA).
of Gene subgroup SMGs symbol Hypermutated/ 21 PTEN microsatellite- PIK3CA unstable PIK3R1 ARID1A RPL22 KRAS ZFHX3 ARID5B CTCF CTNNB1 ATR GIGYF2 CSDE1 FGFR2 CCND1 LIMCH1 RBMX NKAP HIST1H2BD TNFAIP6 MIR1277 Copy number low/ 16 PTEN microsatellite- PIK3CA stable CTNNB1 ARID1A PIK3R1 CTCF KRAS FGFR2 CHD4 SPOP CSMD3 (b) SOX17 SGK1 BCOR MECOM METTL14 Copy number high 8 TP53 (serous-like) PIK3CA FBXW7 PPP2R1A PIK3R1 CHD4 PTEN CSMD3 (b) Molecular Gene name Somatic-mutation subgroup frequency Hypermutated/ Phosphatase and tensin homolog 87.