CCL5


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CCL5

A gene on chromosome 17q11.2-q12 that encodes a cytokine that is a chemoattractant for monocytes, memory T helper cells and eosinophils. CCL5 triggers the release of histamine from basophils and activates eosinophils, is produced by CD8+ T cells and is a major HIV-suppressive factor. It binds to the chemokine receptor CCR5, and suppresses in vitro replication of R5 strains of HIV-1, which use CCR5 as a coreceptor.
References in periodicals archive ?
today announced the publication of preclinical data showing that CT-2009 disrupts heteromers formed by the platelet-derived chemokines CCL5 (RANTES) and CXCL4, thereby preventing lung damage in multiple mouse models of acute lung injury (ALI).
Interleukin-8 (IL-8) was measured in culture supernatant by ELISA, while mRNA from cells was subjected to quantitative reverse transcriptase PCR for several other chemokines (CXCL1, CCL5 and CXCL5) and for Toll-like receptors (TLR) 2, 4, 5 and 9.
The work on this molecule suggests that CCL5 and/or related proteins may lead to new therapies that help the immune system resist TB.
CCL5 is a member of a large family of proteins responsible for immune cell migration toward infection sites.
Scientists discovered the role and potential benefits of CCL5 by studying mice lacking the gene to make the CCL5 protein and mice with the CCL5 gene.
4] also induced expression of CCL11, CCL5, CCL3, and CXCL2, and BB exposure resulted in upregulation of CCL4.
CCL17 and CCL5 were shown to be involved in a mouse model of allergic contact dermatitis (37).