CCL5


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CCL5

A gene on chromosome 17q11.2-q12 that encodes a cytokine that is a chemoattractant for monocytes, memory T helper cells and eosinophils. CCL5 triggers the release of histamine from basophils and activates eosinophils, is produced by CD8+ T cells and is a major HIV-suppressive factor. It binds to the chemokine receptor CCR5, and suppresses in vitro replication of R5 strains of HIV-1, which use CCR5 as a coreceptor.
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The analysis revealed an increased expression of CCL5 and CCR5 in patients with basal and HER-2 subtypes, with 58 percent indicating a positive CCR5 and CCL5 signature.
Bacteria effect on gene expression of CXCL1, CCL5 and CXCL5: Significant upregulation of gene expression for CXCL1 was noted in response to S.
The expression of CCL5, a chemoattractant of T lymphocytes, was not increased in response to any of the bacteria.
The findings of this study suggest that humans who carry mutations in CCR5 may also experience problems with wound healing, and identify the CCR5 or CCL5 as a potential clinical target to promote healing.
Expression of mRNA was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) for the following: CXCL10, CCL3, CCL4, CCL5, CCR1, CCR4, CCR5, CXCR3 and [beta]-actin.
tuberculosis (48) los M[FI] humanos infectados normalmente producen CCL2, CCL3, CCL4 y CCL5 (MCP1, MIP1[alfa], MIP1[beta] y RANTES) en respuesta a cepas virulentas de M.
With regard to chemokines, recent studies indicate that polymorphisms in CCL5 may alter the likelihood and the course of HIV-1 infection (13).
3 CXCL10 ([dagger]), N = 232-1,019 26,319 16,156 CCL2 ([dagger]), N = 18-152 445 257 CXCL9 ([dagger]), N = 37-463 1,138 1,605 CCL5, N = 10,349-46,704 24,745 60,671 * N, normal range; IFN, interferon; IL, interleukin; UD, undetected; TNF, tumor necrosis factor.
TREM-1 cross-linking has been associated with an induced release of inflammatory cytokines such as TNF-[alpha], IL-6, and chemokines such as CXCL8, CCL4, and CCL5.
They have found that the protein CCL5 plays a protective role in helping the body ward off this contagious, airborne disease in the early stages of infection.
4,32) De estas sustancias, las que participan en la inmunopatogenesis de la psoriasis incluyen CCL17, CXCL9 (monoquina inducida por interferon [gamma]), CXCL10, CCL22, CCL5, CCL27 (quimioquina atrayente de la celula T cutanea), CCL20 (proteina inflamatoria del macrofago), CCL19 y CXCL8 (quimioquina atrayente del neutrofilo).
4] also induced expression of CCL11, CCL5, CCL3, and CXCL2, and BB exposure resulted in upregulation of CCL4.