CCL3


Also found in: Acronyms.

CCL3

A gene on chromosome 17q12 that encodes a small inducible cytokine, commonly known as macrophage inflammatory protein 1 (MIP-1) alpha, which is produced by CD8+ T cells and is a major HIV-suppressive factor. It binds to chemokine receptors CCR1, CCR4 and CCR5.
References in periodicals archive ?
Similarly, the expression of 18 cytokine genes (IL-7, IL-10, TNFAIP8, SPP2, TNFAIP3, IFNB, CCL19, TNFAIP8L1, IL-16, CNTF, CXCL13, TNFAIP8L3, TNFSF13B, IL-34, TGFB1, TNFAIP2, CCL3, and ADIPOQ) and 39 cytokine receptor genes (CXCR7, CSF2RA, IL-1RL1, I-L1R2, IL-17RA, IFNAR1, IL-18RAP, IL-31RA, IL-9R, IL-18R1, IL-20RB, IL-21R, IL-2RG, IL-20RA, IL-4I1, LILRB1, TLR1, IL-17REL, LILRB5, TGFBR1, TLR6, TNFRSF13B, XCR1, TLR7, TNFRSF13C, TLR15 etc.
4] also induced expression of CCL11, CCL5, CCL3, and CXCL2, and BB exposure resulted in upregulation of CCL4.
Yine onernli bir inflamatuvar sitokin olan CCL3 kemokini makrofaj inflamatuvar protein-1 alpha'nin da idiyopatik PAH hastalannin akciger biyopsilerinde ekspresyonunun arttigi gosterilmistir (42).
Other macrophage-related cytokines induced under hypoxic conditions are tumour necrosis factor (TNF)[alpha], interferon (IFN)[gamma], interleukin (IL)-10 and arginase [16,17] and the chemokines CXCL1, CCL3, CXCL8 (IL-8), and CXCL12 with its receptor CXCR4.