CCL26


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CCL26

A gene on chromosome 7q11.23 that encodes eotaxin-3, a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL26 binds CCR3 and is chemotactic for eosinophils and basophils.
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Chemokines whose concentrations were measured in the present study included CXCL8 (IL-8), CXCL9 (monokine induced by gamma interferon), CXCL10 (interferon-gamma-induced protein 10 [IP-10]), CXCL11 (interferon-inducible T-cell alpha chemoattractant), CCL4 (macrophage inflammatory protein 1[sz] [MIP-1[sz]]), CCL11 (eotaxin-1), CCL26 (eotaxin-3), CCL17 (thymus and activation-regulated chemokine [TARC]), CCL22 (macrophage-derived chemokine [MDC]), CCL2 (monocyte chemoattractant protein 1 [MCP-1]), and CCL13 (MCP-4).
Meso scale discovery (MSD) system (MSD, Rockville, MD, USA)[sup][12] was used to measure the concentrations of proinflammatory cytokines and chemokines for IL-1[sz], IL-6, IL-17, IL-18, TNF-a, CXCL8, CXCL10, CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 using a commercial kit (K15054G-2).
Concentrations of CC chemokines CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 in bronchoalveolar lavage fluid
genes de quimiocinas CCL5/RANTES, CCL11, CCL24, CCL26, filagrina e outros) e (d) associados a funcao pulmonar e remodelamento bronquico (ADAM-33, DPP-10 e HLA-G, dentre outros).