CCL25


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CCL25

A gene on chromosome 19p13.2 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL25 binds CCR9; it is chemotactic for dendritic cells, thymocytes and activated macrophages, but not lymphocytes and neutrophils.
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Women had about 20% less CCL25 and CCL26 than men, and 32% less CxCL1 (fracktalkine).
29) The [alpha]4[beta]7 specifically binds MAdCAM-1, and CCR9 is the receptor for the chemokine CCL25 secreted by small intestinal venules.
Benzerdurum T hucrelerinde kemokin reseptoru CCR9 ekspresyonunun artmasi ve bu kemokinin ince barsak epitelyal hucreleri tarafindan uretilen CCL25 kemokinine afinitesi ile aciklanmaktadir.
1, 2008, issue of Clinical Cancer Research, also suggests that merging of the protein, called CCR9, with the CCL25 protein, which is known to play a role in the development of disease-fighting white blood cells, may help to explain the high incidence of melanoma metastasis to the lower bowel.
It used various techniques, such as molecular biology, immunostaining and laboratory functional studies, to assess tumors for the two proteins; CCL25 is important because it often is produced in the small intestine--particularly during inflammation.