CCL22


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CCL22

A gene on chromosome 16q13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL22 binds CCR4 and is chemotactic for monocytes, dendritic cells, natural killer cells and activated T lymphocytes—but not for neutrophils, eosinophils or resting T lymphocytes. CCL22 may also play a role in trafficking activated T lymphocytes to sites of inflammation.
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Results: The concentrations of IL-1, TNF-a, IL-6, CXCL8 and CXCL10, and CCL4, CCL11, CCL17, and CCL22 were significantly elevated in asthmatics compared with controls (P < 0.
mRNA levels of IGF-1 and CCL22 (wound healing macrophages [WHM]) were significantly down-regulated in MAL-mice, while regulatory macrophage marker (RM) CCL-1 and the classically activated macrophages (CAM) marker, CCLX10, were higher than the control.
Lower serum levels of Th2-related chemokine CCL22 in women patients with multiple sclerosis: a comparison between patients and healthy women.
IL-4 induced M2 macrophages expressed high concentration of IL-10, decoy receptor IL-1R, IL-1R antagonist, chemokines CCL22 and CCL17, and intracellular enzyme arginase-1.
A 215 bp band around CCL22 16C/A locus was amplified using primer pairs 5'-TGGGAGGTAGTTCTTCTTTTGA-3' (forward) and 5'-CCACAGCAAGGAGGACGA-3' (reverse).
16,20) HTLV-1 is proposed to induce and maintain high levels of FOXP3 through chemokine CCL22 expression.
They developed a system of polymer microspheres to slowly release a chemokine, or signaling protein, called CCL22 that attracts regulatory T-cells, and placed tiny amounts of the paste-like agent between the gums and teeth of animals with periodontal disease.
They used a modified virus to insert the gene for a protein called CCL22 into the beta cells of a strain of mice known to develop diabetes.
4,32) De estas sustancias, las que participan en la inmunopatogenesis de la psoriasis incluyen CCL17, CXCL9 (monoquina inducida por interferon [gamma]), CXCL10, CCL22, CCL5, CCL27 (quimioquina atrayente de la celula T cutanea), CCL20 (proteina inflamatoria del macrofago), CCL19 y CXCL8 (quimioquina atrayente del neutrofilo).
4] and BB treatment (IL8, CCL17, TNFRSFIA, CCR7, CCL22, CD86, CXCR4, and PPIA) might be candidates for a general identification of sensitizing chemicals.
These infiltrated Tregs respond to CCL17 and CCL22 released by activated DCs, thus resulting in their accumulation in the liver with dendritic cells-rich inflammatory infiltrates.