CCL22


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CCL22

A gene on chromosome 16q13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL22 binds CCR4 and is chemotactic for monocytes, dendritic cells, natural killer cells and activated T lymphocytes—but not for neutrophils, eosinophils or resting T lymphocytes. CCL22 may also play a role in trafficking activated T lymphocytes to sites of inflammation.
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4] and BB treatment (IL8, CCL17, TNFRSFIA, CCR7, CCL22, CD86, CXCR4, and PPIA) might be candidates for a general identification of sensitizing chemicals.
CCL22 and CCL17 are the most abundant chemokines produced by DCs (34).
Dendritic cells as a major source of macrophage-derived chemokine/ CCL22 in vitro and in vivo.
Plovamer acetate causes a more pronounced increase in eosinophils and CCL22 in naive and EAE mice compared with glatiramer acetate (Poster P398, Experimental Models; Thursday, September 11, 3:30 C 5:00 p.
They developed a system of polymer microspheres to slowly release a chemokine, or signaling protein, called CCL22 that attracts regulatory T-cells, and placed tiny amounts of the paste-like agent between the gums and teeth of animals with periodontal disease.
They used a modified virus to insert the gene for a protein called CCL22 into the beta cells of a strain of mice known to develop diabetes.
In contrast to ALK+ ALCL, there was also lower expression of cytotoxic molecules, cathepsins, and Th17 cell-associated molecules, and higher expression of some cytokines/receptors (CCL1, CCL22, CCR8, CCR4, IL-13RA2, CXCL14, TGF-bR1) and antiapoptotic molecules (BCL2, BIRC6, BIC), and lower expression of some proapoptotic genes (BAX, BCL2L1, BNPIP3).