CCL21


Also found in: Encyclopedia, Wikipedia.

CCL21

A gene on chromosome 9p13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL21 binds CCR7, inhibits haemopoiesis and is chemotactic for thymocytes and activated T cells—but not B cells, macrophages or neutrophils; it may also play a role in homing lymphocytes to secondary lymphoid tissue.
Mentioned in ?
References in periodicals archive ?
Steven Dubinett, Professor & Chief, Division of Pulmonary & Critical Care Medicine, UCLA Department of Medicine have demonstrated that intratumoral administration of CCL21 gene-modified dendritic cells led to tumor eradication.
CCL21 potently activates resident microglia within the ventral posterolateral (VPL) nucleus of the thalamus as well as the lumbar dorsal horn, and in turn, microglia pathologically modulate the firing properties of nociceptive neurons at these locations.