CCL20


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CCL20

A gene on chromosome 2q33-q37 that encodes a chemotactic factor that attracts lymphocytes and neutrophils, but not monocytes. CCL20 inhibits proliferation of myeloid stem cells in colony formation assays, and may be involved in proliferation and activity of mucosal lymphoid tissues (e.g., BALT, MALT, SALT) by attracting lymphocytes and dendritic cells towards epithelial cells.
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In vitro stimulation of Th17 or Tc17 cells in the presence of Lycera's RORgamma agonists increased the expression of costimulatory molecules and production of immune-enhancing cytokines, such as IL-17A, IL-17F, GM-CSF and CCL20, maintained IFNgamma production, and decreased expression of coinhibitory molecules, including PD-1, and the development of regulatory immune cells.
In contrast, 18 cytokines genes (BMPER, CCL19, CCL20, CCL4, CXCL14, IFNB, IL-12A, IL-17B, IL-17D, IL-17F, IL-19, IL-22, IL-26, IL-7, LIF, NLRC3, TGFA, and VEGFA) and 14 receptor genes (CXCR3, IFITM5, IL-13RA1, IL-17RC, IL-1RAPL2, IL-22RA1, IL-22RA2, ILDR1, LILRA5, LTBP2, PDGFD, PDGFRL, TNFRSF14, and TNFRSF6B) were markedly downregulated by 2.
DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-alpha-induced 1L-8 and CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cells.
The study, performed in mouse models for asthma research, showed that the synthetic sulfate monosaccharide blocks the interaction between chemokine CCL20-a T-cell signaling protein and heparin sulfate, a molecule that protects and immobilizes CCL20 on epithelial cells in the lung.
CCL20, [gamma][delta] T cells, and IL-22 in corneal epithelial healing.
Harper EG, Guo C, Rizzo H, et al: Th17 cytokines stimulate CCL20 expression In keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis.
48) Ultraviolet light induces CCL27 (cutaneous T cell-attracting chemokine) and CCL20 (macrophage inflammatory protein 3[alpha]), an important chemokine for Langerhans cells, as well as CCL2 and CCL5.
Meanwhile, extracts were unable to reverse activation-induced TGFP2 and CCL20 expression.
78 0 beta 2 CCL20 Chemokine (C-C motif) ligand 20 +4.
Choi and his colleagues demonstrated that DA-9601 - a standardized aqueous extract of Artemisia asiatica, blocks TNF-[alpha]-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF[kappa]B pathways in human gastric epithelial cells (Choi et al.