CCL2


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CCL2

A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.
References in periodicals archive ?
The latter is important, as proteins previously identified as potential biomarkers for endometriosis such as the chemokines CXCL8, CCL2, and CCL5 vary during the menstrual cycle which practically limits their diagnostic value.
13 Recent study found that ACKR1 polymorphism is associated with serum concentration of CCL2 belonging to the CC family.
10] More interestingly, some studies showed the SNP (single nucleotide polymorphism) subtypes, rs4795893, rs1024611, rs4586 and rs2857657, of CCL2, the coding gene of MCP-1, were associated with treatment resistance of risperidone in the Han Chinese population.
Recent studies have found that ACKR1 polymorphism is associated with serum levels of CCL2 belonging to the CC family (29,30).
12) Thus, CCL2 produced by pancreatic acinar cells emerged as the key pathogenic chemokine in the development of acute pancreatitis induced by simultaneous activation of NOD1 and CCKR.
Serum CCL2 and serum TNF-a-two new biomarkers predict bone invasion, post-treatment distant metastasis and poor overall survival in nasopharyngeal carcinoma.
Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions.
20) have investigated the effects of IVMP treatment for 5 days on IL-12 and IL-10 levels and CCL2 chemokine expressions.
2015) 2/3 HTP assays Two key signaling available for pathways that primary angiogenic interact: VEGFRand pathway TGF- mediated molecular signaling targets: pathways leading VCAM, CXCL9 to the creation of and, THBD, the tumor microenvironment CCL2, ICAM, and uPAR, col111, angiogenesis CXL10, MMP1, AhR (role in cell cycle regulation) miRNA target genes involved in angiogenesis (Caporali and Emanueli, 2011) Potential adaptation of Hen's egg test-chorioallantoic membrane (HET-CAM) 2 Assays available Caspase pathway, for, e.
CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance.
It was found that all compounds under study inhibited proliferation of CCL2 in a dose-dependent mode in 72 h after their addition to the culture medium.