CCL2


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CCL2

A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.
References in periodicals archive ?
In this scenario, the CCL2 (chemokine [C-C motif] ligand 2), through its functional receptor (CCR2) induces monocyte recruitment, inflammation and metabolic stress Qoven et al.
Abstract number RS-2026 (oral presentation, April 23, 4:15 PM) CCR2+ infiltrating monocytes promote acetaminophen-induced actue liver injury -- therapeutic implications of inhibiting CCR2 and CCL2 O.
CCL2 (monocyte chemoattractant protein 1, MCP-1), implicated in a number of diseases has in its mature form an N-terminal pGlu.
Several studies have shown an important role of adipose tissue macrophages in inflammation in obesity through the production and release of proinflammatory mediators such as IL-1, TNF-[alpha], IL-6, and CCL2 (Hrnciar et al.
Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity.
The association of SNPs in the chemokine CCL2 and caspase recruitment domain CARD15 genes with milk production traits was found in Canadian Holstein cattle (Leyva-Baca et al.
Although the direct association between HPV infection and inflammation is controversial, transgenic mouse models, expressing the early genes from HPV 16 under the control of the human keratin 14 promoter, have shown that HPV-induced lesions release the chemokine CCL2 which enhances macrophage recruitment into tumours via CCR2.
The use of the protein, known as CCL2, could make it easier to culture human pluripotent cells, which are more difficult to cultivate than those of mice, according to researchers at the government-backed institute.
Hyper-responsiveness of IPF/ UIP fibroblasts: interplay between TGF-beta1, IL-13 and CCL2.
inhibits the ability of this viral protein to bind CCL2.
Viral expression of CCL2 is sufficient to induce demyelination in RAG 1-/- mice infected with a neurotropic coronavirus.
48) Ultraviolet light induces CCL27 (cutaneous T cell-attracting chemokine) and CCL20 (macrophage inflammatory protein 3[alpha]), an important chemokine for Langerhans cells, as well as CCL2 and CCL5.