CCL19


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CCL19

A gene on chromosome 9p13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL19 binds CCR7, and may play a role in normal lymphocyte recirculation and homing, in trafficking of T cells in the thymus, and in T-cell and B-cell migration to secondary lymphoid tissue.
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The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro.
2,17) In the peripheral lymph nodes, LFA-1 on T cells is activated when HEV-associated chemokines including CCL21/ CCL19 and CXCL12 interact with their specific receptors on T cells, CCR7 and CXCR4, respectively, whereas LFA-1 on B cells is activated by interactions with CXCL13 via CXCR5.
This would make an up-regulation of CXCR4 or CCR7 and their respective chemokine ligands (CXCL12, CCL19 and CCL21) (Lin et al.
CCR7 has been detected in various immune cells and promotes cell migration toward CCL19 and CCL21, which are considered as inflammatory cytokines due to the fact that they appear in most chronically inflamed organs [2].
In contrast, 18 cytokines genes (BMPER, CCL19, CCL20, CCL4, CXCL14, IFNB, IL-12A, IL-17B, IL-17D, IL-17F, IL-19, IL-22, IL-26, IL-7, LIF, NLRC3, TGFA, and VEGFA) and 14 receptor genes (CXCR3, IFITM5, IL-13RA1, IL-17RC, IL-1RAPL2, IL-22RA1, IL-22RA2, ILDR1, LILRA5, LTBP2, PDGFD, PDGFRL, TNFRSF14, and TNFRSF6B) were markedly downregulated by 2.
Este estudio nos permitio identificar niveles aumentados de transcritos para CCL19 y CCL20.
a) CCL19 CDH7 COL2A1 COL9A2 COMP Gleason score C N C N C N C N C N 6 1 2 -- 1 3 3 1 2 0 0 6 2 1 1 3 3 1 2 1 1 1 6 3 1 2 1 3 1 3 1 1 0 6 2 2 1 1 3 2 1 1 1 1 6 1 1 0 1 1 1 1 1 0 0 6 1 1 0 1 2 1 2 1 0 0 6 1 2 1 1 1 1 2 2 0 0 6 1 1 2 1 2 1 2 1 1 0 7 2 1 1 2 3 2 2 1 1 0 7 2 2 1 1 3 2 2 2 1 1 7 3 2 1 1 3 2 2 1 1 1 7 2 2 2 2 3 2 3 2 2 2 7 3 1 1 1 3 1 1 1 1 1 7 1 1 1 2 3 2 1 1 1 1 7 2 1 1 1 3 1 2 2 2 1 8 2 1 2 1 2 1 1 1 1 2 8 2 1 3 1 3 2 2 2 2 1 9 2 2 1 2 3 1 2 2 1 2 10 1 1 2 1 3 1 2 1 2 1 10 2 1 0 -- 3 -- 1 -- 1 1 C>N, n 9 5 16 (b) 8 9 (b) N>C, n 2 7 0 1 0 P 0.
2] receptor for NE, inhibited the DC release of the inflammatory chemokines CCL19 and CCL21 in vitro [23].
4,32) De estas sustancias, las que participan en la inmunopatogenesis de la psoriasis incluyen CCL17, CXCL9 (monoquina inducida por interferon [gamma]), CXCL10, CCL22, CCL5, CCL27 (quimioquina atrayente de la celula T cutanea), CCL20 (proteina inflamatoria del macrofago), CCL19 y CXCL8 (quimioquina atrayente del neutrofilo).
Moreover, the expression of CCR7 and CXCR4 on circulating T-cells, the increase of CXCL12 plasma concentration and the production of CCL19 and/or CCL21 mRNA in lymph nodes also suggest homing into secondary lymphoid organs.
47),(68),(69) The interaction between chemokines produced in the interfollicullar region of the PPs and chemokine receptors, such as between CCL19 and CCR7 and between CCL20 and CCR6, plays an important role in the transport of dendritic cells to T cell zones.
The expression of CCR7 along with the maturation of DCs and their responsiveness to CCL19 was also published by Dieu et al.