CCL19


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CCL19

A gene on chromosome 9p13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL19 binds CCR7, and may play a role in normal lymphocyte recirculation and homing, in trafficking of T cells in the thymus, and in T-cell and B-cell migration to secondary lymphoid tissue.
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In contrast, 18 cytokines genes (BMPER, CCL19, CCL20, CCL4, CXCL14, IFNB, IL-12A, IL-17B, IL-17D, IL-17F, IL-19, IL-22, IL-26, IL-7, LIF, NLRC3, TGFA, and VEGFA) and 14 receptor genes (CXCR3, IFITM5, IL-13RA1, IL-17RC, IL-1RAPL2, IL-22RA1, IL-22RA2, ILDR1, LILRA5, LTBP2, PDGFD, PDGFRL, TNFRSF14, and TNFRSF6B) were markedly downregulated by 2.
Similarly, the expression of 18 cytokine genes (IL-7, IL-10, TNFAIP8, SPP2, TNFAIP3, IFNB, CCL19, TNFAIP8L1, IL-16, CNTF, CXCL13, TNFAIP8L3, TNFSF13B, IL-34, TGFB1, TNFAIP2, CCL3, and ADIPOQ) and 39 cytokine receptor genes (CXCR7, CSF2RA, IL-1RL1, I-L1R2, IL-17RA, IFNAR1, IL-18RAP, IL-31RA, IL-9R, IL-18R1, IL-20RB, IL-21R, IL-2RG, IL-20RA, IL-4I1, LILRB1, TLR1, IL-17REL, LILRB5, TGFBR1, TLR6, TNFRSF13B, XCR1, TLR7, TNFRSF13C, TLR15 etc.
3, while the gene expression levels of 16 genes (IL-10, SPP2, CMC1, IL-19, LIF, TAP1, IFNG, IL-6, FASLG, IL-7, CCL19, TNFAIP8L3, IL-34, CCL3, IL-10, and SPP2) were higher in line 7.
a) CCL19 CDH7 COL2A1 COL9A2 COMP Gleason score C N C N C N C N C N 6 1 2 -- 1 3 3 1 2 0 0 6 2 1 1 3 3 1 2 1 1 1 6 3 1 2 1 3 1 3 1 1 0 6 2 2 1 1 3 2 1 1 1 1 6 1 1 0 1 1 1 1 1 0 0 6 1 1 0 1 2 1 2 1 0 0 6 1 2 1 1 1 1 2 2 0 0 6 1 1 2 1 2 1 2 1 1 0 7 2 1 1 2 3 2 2 1 1 0 7 2 2 1 1 3 2 2 2 1 1 7 3 2 1 1 3 2 2 1 1 1 7 2 2 2 2 3 2 3 2 2 2 7 3 1 1 1 3 1 1 1 1 1 7 1 1 1 2 3 2 1 1 1 1 7 2 1 1 1 3 1 2 2 2 1 8 2 1 2 1 2 1 1 1 1 2 8 2 1 3 1 3 2 2 2 2 1 9 2 2 1 2 3 1 2 2 1 2 10 1 1 2 1 3 1 2 1 2 1 10 2 1 0 -- 3 -- 1 -- 1 1 C>N, n 9 5 16 (b) 8 9 (b) N>C, n 2 7 0 1 0 P 0.
Moreover, the expression of CCR7 and CXCR4 on circulating T-cells, the increase of CXCL12 plasma concentration and the production of CCL19 and/or CCL21 mRNA in lymph nodes also suggest homing into secondary lymphoid organs.
Similarly, the production of CCL19 in the ileum and the rectum and that of CCL21 in the jejunum suggest that R-sIL-7gly injection also triggers T-cell migration into the lymphoid follicles of the gut, where massive T-cell proliferation subsequently occurs.
The expression of CCR7 along with the maturation of DCs and their responsiveness to CCL19 was also published by Dieu et al.
CCL19 induces rapid dendritic extension of murine dendritic cells.