CCL28

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CCL28

A gene on chromosome 5p12 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL28 binds CCR3 and CCR10, and is chemotactic for resting CD4 or CD8 T cells and eosinophils; it may play a role in the physiology of extracutaneous epithelia, including mucosal tissues.
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Above pancreatostimulatory effects of luminal administration of melatonin, were completely reversed by bilateral vagotomy, capsaicin deactivation of sensory nerves or pretreatment of the rats with CCK1 receptor antagonist; tarazepide as well as serotonin antagonist; ketanserin.
Involvement of endogenous CCK and CCK1 receptors in colonic motor function.