CCR3

(redirected from CC chemokine receptor)

CCR3

A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for C-C-type chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5). It is highly expressed in eosinophils and basophils, as well as in TH1 cells, TH2 cells and airway epithelial cells; it may contribute to the accumulation and activation of eosinophils and other inflammatory cells in airways allergies, and is also an entry co-receptor for HIV-1.
References in periodicals archive ?
ATLANTA -- Intravenous treatment with mogamulizumab, an investigational antibody targeting CC chemokine receptor 4, more than doubled progression-free survival (PFS), compared with oral vorinostat in a phase 3 trial of 372 patients with heavily pretreated cutaneous T-cell lymphoma (CTCL).
Mogamulizumab is a humanised monoclonal antibody (mAb) that is directed against CC chemokine receptor 4 (CCR4), which is frequently expressed on leukemic cells of certain haematologic malignancies, including CTCL.
18] Other studies also found that receptors of MCP-1, CC chemokine receptor type 1 (CCR1) and CC chemokine receptor type 2 (CCR2), were expressed on the ventral midbrain of humans.
We have reported that stimulation by fibronectin increases the release of CCL2 from activated microglia, and CCL2 stimulates the CC chemokine receptor CCR2 of microglia resulting in the stimulation of P2X4R trafficking to the cell surface from lysosomes of microglia (38) (Fig.
These cytokines stimulate the generation of eotaxin, which acting on CC chemokine receptor 3 (CCR3) on eosinophilsthen stimulate the migration of eosinphils into the lung tissue.
CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis.
The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/ lymphoma.
The study was carried out on 14 patients with histopathologically confirmed head and neck squamous cell carcinoma (HNSCC) and ten healthy individuals (control) matched for age to determine the following : (i) The status of CC chemokine receptor CCR5 and its ligands MIP-1[alpha] and RANTES
For initial therapy, the panelists do not recommend using PI/r monotherapy or maraviroc, a CC chemokine receptor 5 (CCR5) antagonist that was approved by the Food and Drug Administration in 2007.
CC chemokine receptor 5 (CCR5) is involved in the chemotaxis of leukocytes towards inflammatory sites (Baggiolini, 1998), and is present only in certain cell types, such as lymphocytes, dendritic cells and macrophages (Loetscher et al.
Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice.
8 molecule 1 Chemokines E13732 CC chemokine receptor 1.