CCR3

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CCR3

A gene on chromosome 3p21.3 that encodes a G protein-coupled receptor for C-C-type chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5). It is highly expressed in eosinophils and basophils, as well as in TH1 cells, TH2 cells and airway epithelial cells; it may contribute to the accumulation and activation of eosinophils and other inflammatory cells in airways allergies, and is also an entry co-receptor for HIV-1.
References in periodicals archive ?
The study was carried out on 14 patients with histopathologically confirmed head and neck squamous cell carcinoma (HNSCC) and ten healthy individuals (control) matched for age to determine the following : (i) The status of CC chemokine receptor CCR5 and its ligands MIP-1[alpha] and RANTES
For initial therapy, the panelists do not recommend using PI/r monotherapy or maraviroc, a CC chemokine receptor 5 (CCR5) antagonist that was approved by the Food and Drug Administration in 2007.
CC chemokine receptor 5 (CCR5) is involved in the chemotaxis of leukocytes towards inflammatory sites (Baggiolini, 1998), and is present only in certain cell types, such as lymphocytes, dendritic cells and macrophages (Loetscher et al.
The CC chemokine receptor 5 (CCR5) delta 32 variant results in a non-functional form of the chemokine receptor, which is incapable of binding beta chemokines (RANTES, MIP-1alpha, MIP-1beta).
Analysis of the CC chemokine receptor 5 delta32 polymorphism in a Brazilian population with cutaneous leishmaniasis.
However, several newer mechanisms of action are now attracting serious attention from the industry, including CC chemokine receptor 5 antagonism, gp120 inhibition and HIV integrase inhibition, with 11, 11 and 7 candidates, respectively.
Malaria enhances expression of CC chemokine receptor 5 on placental macrophages.
The first co-receptor that HIV latches onto to enter the cell is called CC chemokine receptor 5 [CCR5].
Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5- studies in populations with quantified risk.