RUNX3

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RUNX3

A gene on chromosome 1p36 that encodes a member of the runt domain-containing family of transcription factors. A heterodimer of RUNX3 and a beta subunit form a complex found in a number of enhancers and promoters, and together either activate or suppress transcription. RUNX3 is a tumour suppressor which also interacts with other transcription factors. 

Molecular pathology
RUNX3 deletion or transcriptional silence may be associated with cancer.