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APD371, an orally available agonist of the CB2 receptor, is an internally discovered investigational drug candidate that Arena is exploring for potential development in several indications, including pain.
It is possible that we will see additional outbreaks of unusual toxicities not related to CB1 or CB2 receptor physiology.
The effect of CBD BDS and CBD on colorectal cancer cell proliferation is counteracted by selective cannabinoid CB, and CB2 receptor antagonists
To better understand the connection between inflammation and neurocognitive conditions linked to long-term exposure to HIV, Ramirez and colleagues looked specifically at the CB2 receptor, a protein located on the surface of macrophages.
The CB1 receptor is expressed mainly in the brain, central nervous system, and the CB2 receptor in the immune system.
This study provides robust evidence that the CB2 receptor is cardinal for moderating neuropathic pain," comments George Fink of the pharmaceutical company Pharmos based in Iselin, N.
In this trial, APD371 was well tolerated, as evidenced by the lack of dose-limiting adverse events, at drug levels greatly exceeding those anticipated as needed for activating the CB2 receptor," said William R.
Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats.
The authors concluded that CB2 receptor activity modulation reduced impulsive behaviour in mice, depending on the patterns that governed the administration of each drug.
Other dextrocannabinoid compounds and CB2 receptor agonist compounds from Pharmos' proprietary synthetic cannabinoid library are being studied in pre-clinical programs targeting a variety of other disorders.
Resunab binds to the CB2 receptor of immune cells and triggers a process known as "inflammatory resolution," in effect turning chronic inflammation "off.
In addition, the CB2 receptor agonists reduced the bouts and amount of drug intake in normal (wild type) mice and mice who lacked the CB1 receptors, but not those that lacked CB2 receptors.
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