CA12

(redirected from CAXII)

CA12

A gene on chromosome 15q22 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate various biological processes, including respiration, calcification, maintaining acid-base balance, bone resorption and producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. The CA12 product is a type-I membrane protein which is highly expressed in normal tissues, such as kidney, colon and pancreas.

Molecular pathology
CA12 is overexpressed in 10% of clear cell carcinomas of the kidney.
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Kim et al (271) evaluated a set of immunohistochemical markers including Ki-67, CAIX, CAXII, p53, PTEN, gelsolin, EpCAM, and vimentin in combination with established parameters.
Kim et al (148) evaluated a set of ICH markers, including Ki-67, CAIX, CAXII, p53, PTEN, gelsolin, EpCAM, and vimentin, in combination with established parameters.
Current and Emerging Prognostic Parameters in Clear Cell Renal Cell Carcinoma (ccRCC) Current Prognostic Parameters in ccRCC Patient factors Age Sex Pathologic factors pTNM Histologic type Fuhrman grade LVI Tumor necrosis Clinical factors ECOG performance status Hgb level Serum lactate dehydrogenase Emerging Potential Molecular Prognostic and Predictive Parameters in ccRCC Hypoxia inducible HIF1 CAIX CAXII CXCR4 VEGF/VEGFR-R ILGF1 Cell adhesion markers EpCAM E-cadherin [alpha]-Catenin Catenin-6 Proliferation markers Ki-67 MCM2 Cell cycle regulators Cyclin p27 Apoptosis regulators p53 Bcl2 Smac/DIABLO mTOR pathway PTEN Akt Phos S6k an Abbreviations: ECOG, Eastern Cooperative Oncology Group; Hgb, hemoglobin; LVI, lamina propria invasion.