CATERPILLER family

CATERPILLER family

A popular term for a group of proteins with a nucleotide-binding domain and a leucine-rich region, which have an array of confirmed and putative roles in immunity, cell death and growth. CATERPILLER proteins are structurally similar to apoptotic protease activating factor 1 (APAF1), up- and downregulate immune and inflammatory responses, and might be intracellular sensors of pathogens.
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Pyrin domain containing 3 (NLRP3), coding NLRP3 protein, is a member of the NALP subfamily in the CATERPILLER family (Ting et al.
NLRP3 is a member of the CATERPILLER family of genes encoding proteins that comprise a nucleotide-binding domain and a leucine-rich repeat domain.