CASP9

CASP9

A gene on chromosome 1p36.21 that encodes a ubiquitous protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis. CASP9 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is processed by APAF1, an early step in the caspase activation cascade. It is highly expressed in the heart.
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2], XIAP, BAX, CASP3, CASP8, CASP9, FOXA2, HNF4A, EBP, HGF, NFKB2, STAT3, IL6, I[L.
Meanwhile, treatment of endothelial cells with autophagy inhibitor 3-methyladenine (3-MA) blocked EGCG-induced expression of CASP9.
RT-PCR was performed for ICAM1, VCAM1, CCL2, BCL2, BAX and CASP9.
Effects of EGCG and L-theanine on TNF-[alpha]-induced BCL2, BAX and CASP9 gene expression in cultured endothelial cells
We also examined the effects of EGCG on BCL2, BAX and CASP9 gene expression following TNF-[alpha] treatment.
Evaluation of the effects of chlorophyllin on apoptosis induction, inhibition of cellular proliferation and mRNA expression of CASP8, CASP9, APC and [beta]-catenin.
TABLA III PATRON DE LATENCIA DEL VIRUS EPSTEIN BARR Y NEOPLASIAS ASOCIADAS Latencia Genes virales Neoplasias asociadas expresados I EBNA-1 Linfoma de Burkit EBERs BARF II EBNA-1 Linfoma de Hodgkin EBERs Cancer nasofaringeo LMP-1 Linfoma periferico LMP-2 T/NK BARF III Todos EBNAs Linfomas asociados a EBERs SIDA LMP-1 Desordenes LMP-2 linfoproliferativos BARF Postransplantes TABLA IV GENES CANDIDATOS Y LINFOMAS FAMILIARES Via Genes Ciclo celular/ AICDA, BAX, BCL2,BCL2A1,BCL2L1,BCL2L2, BCL2L10, Apoptosis BCL2L11(BIM), BCL6, BCL7A, BCL7C, BCL10, CASP1, CASP14, CASP4, CASP5, CASP6, CASP7, CASP8AP2, CASP9, CCND1, LMO2, MYC, PIM1, RIPK1, RIPK2, TP53, TP53I.
The garners needed just three weeks to uncover the structure of the protein CASP9, a key player in the virus that causes simian AIDS.
Active Akt signaling functions to inhibit apoptosis through phosphorylation of proapoptotic factors such as BAD [encoded by BCL2-associated agonist of cell death (BAD)], CASP9 [encoded by caspase 9, apoptosis-related cysteine peptidase (CASP9)], and FOXO1 [encoded by forkhead box O1 (FOXO1)].
Initiator caspases (CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them.
The down-regulated genes were TRAIL, TNFR, AP13, IGFBP3, SARP3, PKB, IGFBP, CASP7, CASP9, TNFSF6, TRICK2A, CAS, TRAIL-R2, RATS1, hTRIP, TNFb and TNFRSF5.