CASP9


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CASP9

A gene on chromosome 1p36.21 that encodes a ubiquitous protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis. CASP9 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is processed by APAF1, an early step in the caspase activation cascade. It is highly expressed in the heart.
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Meanwhile, treatment of endothelial cells with autophagy inhibitor 3-methyladenine (3-MA) blocked EGCG-induced expression of CASP9.
RT-PCR was performed for ICAM1, VCAM1, CCL2, BCL2, BAX and CASP9.
Effects of EGCG and L-theanine on TNF-[alpha]-induced BCL2, BAX and CASP9 gene expression in cultured endothelial cells
We also examined the effects of EGCG on BCL2, BAX and CASP9 gene expression following TNF-[alpha] treatment.
Effects of the autophagy inhibitor 3-MA on EGCG and L-theanine-mediated suppression of TNF-[alpha]-dependent CASP9 gene expression in endothelial cells
Thus, we investigated whether EGCG and L-theanine inhibited the effects of TNF-[alpha] on CASP9 gene expression by pretreating endothelial cells with 3-MA (5 mM).
In addition, TNF-[alpha]; increased BAX and CASP9 expression levels as well as caspase 3/7 activity, and these increases were similarly reduced in the presence of EGCG and L-theanine (Figs.
Evaluation of the effects of chlorophyllin on apoptosis induction, inhibition of cellular proliferation and mRNA expression of CASP8, CASP9, APC and [beta]-catenin.
The garners needed just three weeks to uncover the structure of the protein CASP9, a key player in the virus that causes simian AIDS.
Active Akt signaling functions to inhibit apoptosis through phosphorylation of proapoptotic factors such as BAD [encoded by BCL2-associated agonist of cell death (BAD)], CASP9 [encoded by caspase 9, apoptosis-related cysteine peptidase (CASP9)], and FOXO1 [encoded by forkhead box O1 (FOXO1)].
Initiator caspases (CASP2, CASP8, CASP9, and CASP10) cleave inactive pro-forms of effector caspases, thereby activating them.
The down-regulated genes were TRAIL, TNFR, AP13, IGFBP3, SARP3, PKB, IGFBP, CASP7, CASP9, TNFSF6, TRICK2A, CAS, TRAIL-R2, RATS1, hTRIP, TNFb and TNFRSF5.