CASP8


Also found in: Dictionary, Thesaurus, Encyclopedia.

CASP8

A gene on chromosome 2q33-q34 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis, as well as various stages of embryological development. CASP8 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is involved in the programmed cell death induced by Fas and various apoptotic stimuli. It is highly expressed in peripheral blood leukocytes and in the spleen, thymus and liver.

Molecular pathology
CASP8 has been detected in the insoluble fraction of affected brain regions in Huntington disease, suggesting a role in neurodegenerative diseases.
References in periodicals archive ?
Robust examples from the multiple case-control association studies of common variants include a missense arginine to histidine amino acid change (D302H) in CASP8 associated with a moderate reduction in breast cancer risk [12], a common amino acid change (C557S) in BARD1 which increased breast cancer risk [13], and most recently a variant in RASSF1A associated with early-onset cancer in BRCA1 and BRCA2 mutation carriers [14].
In "A Common Coding Variant in CASP8 is Associated with Breast Cancer Risk," published in the February issue of Nature Genetics, the authors, led by scientists at Sheffield University Medical School, University of Cambridge and National Cancer Institute, found evidence of an association between breast cancer and CASP8 D302H.
Antiapoptosis genes such as CASP8 and FADD-like apoptosis regulator (CFLAR) are induced by PAXgene reagent (see Fig.