CASP7

CASP7

A gene on chromosome 10q25 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of apoptosis. Effector (also called executioner) caspases CASP3, -6 and -7 are responsible for cleaving downstream substrates—CASP7 cleaves and activates sterol regulatory element binding proteins (SREBPs). It is highly expressed in the lung, skeletal muscle, liver, kidney, spleen and heart.
References in periodicals archive ?
TABLA III PATRON DE LATENCIA DEL VIRUS EPSTEIN BARR Y NEOPLASIAS ASOCIADAS Latencia Genes virales Neoplasias asociadas expresados I EBNA-1 Linfoma de Burkit EBERs BARF II EBNA-1 Linfoma de Hodgkin EBERs Cancer nasofaringeo LMP-1 Linfoma periferico LMP-2 T/NK BARF III Todos EBNAs Linfomas asociados a EBERs SIDA LMP-1 Desordenes LMP-2 linfoproliferativos BARF Postransplantes TABLA IV GENES CANDIDATOS Y LINFOMAS FAMILIARES Via Genes Ciclo celular/ AICDA, BAX, BCL2,BCL2A1,BCL2L1,BCL2L2, BCL2L10, Apoptosis BCL2L11(BIM), BCL6, BCL7A, BCL7C, BCL10, CASP1, CASP14, CASP4, CASP5, CASP6, CASP7, CASP8AP2, CASP9, CCND1, LMO2, MYC, PIM1, RIPK1, RIPK2, TP53, TP53I.
11] APP, COL14A1, ROBO1, ITGAV, COL12A1, SCARB1, SCARB2, CNTN3, MFAP4, COL24A1, THBS2 multicellular 46 AEBP1, S100A6, HUS1, UTRN, 0,005 organismal GPM6B, POSTN, FKBP1A, ENPEP, development MYLIP, CBFB, PTK2, APP, ROBO1, CASP7, ITGAV, COL12A1, FBN2, LOX, USH2A, OLFM1, DCLK1, MLLT3, EGFL6, NRXN3, MAP1B, CHODL, ITGA2, AFF3, IGF2, SIRT1, COL5A1, CTNNBIP1, DKK3, MAN2A1, DACT1, CNTF, TMEM111, SFRP2, GRN, IRF1, SORT1, CNTN3, PSME4, COL1A1, CASQ2, MYH10 muscle organ 8 APP, AEBP1, CNTF, UTRN, CHODL, 0,008 development FKBP1A, SIRT1, MYH10 lipid 9 PTGES3, SAMD8, CYB5R1, AGPAT5, 0,026 biosynthetic C1QTNF3, LASS3, ALOX5AP, process SCARB1, ELOVL6 La interpretacion funcional mostro enriquecimiento en funciones estrechamente relacionadas con el desarrollo y adipogenesis del tejido muscular.
The down-regulated genes were TRAIL, TNFR, AP13, IGFBP3, SARP3, PKB, IGFBP, CASP7, CASP9, TNFSF6, TRICK2A, CAS, TRAIL-R2, RATS1, hTRIP, TNFb and TNFRSF5.