CASP6

CASP6

A gene on chromosome 4q25 that encodes a so-called effector caspase belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of apoptosis. Effector (also called executioner) caspases CASP3, -6 and -7 are responsible for cleaving downstream substrates.
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Effector caspases (CASP3, CASP6, CASP7) in turn cleave other protein substrates within the cell, to trigger the apoptotic process.