CASP2


Also found in: Acronyms.

CASP2

A gene on chromosome 7q34-q35 that encodes a member of the cysteine-aspartic acid protease (caspase) family of proteins, which mediate apoptosis by proteolysis of specific protein substrates. CASP2 is involved in stress-induced cell death, cell cycle maintenance and tumour suppression.

Molecular pathology
CASP2 is upregulated in neurodegenerative disorders—e.g., Alzheimer's disease, Huntington's disease and temporal lobe epilepsy.
References in periodicals archive ?
For example, BAK1 and CASP2 are both pro-apoptotic and have been shown to induce apoptosis in vitro and in vivo in several cell types (Kumar 2009; Pataer et al.
It is important to note that these results do not demonstrate that miR-125b directly decreases the expression of BAK1, CASP2, MAP2K7, and MCL1 upon exposure to formaldehyde, nor that miR-142-3p directly increases the expression of ITGB8.
Such is the core of cooperation in the CASP2 framework in each country, together with a number of parallel regional cooperation initiatives and activities.