CASK


Also found in: Dictionary, Thesaurus, Legal, Financial, Acronyms, Idioms, Encyclopedia, Wikipedia.

CASK

A gene on chromosome Xp11.4 that encodes a calcium/calmodulin-dependent serine protein kinase of the membrane-associated guanylate kinase (MAGUK) family, which are scaffold proteins located at synapses in the brain. CASK is involved in synaptic transmembrane protein anchoring and ion channel trafficking; contributes to neural development and regulating gene expression by interacting with the transcription factor TRB1; binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans; and may mediate a link between the extracellular matrix and the actin cytoskeleton with syndecan and the actin/spectrin-binding protein 4.1.
 
Molecular pathology
CASK mutations are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, as well as an X-linked form of mental retardation.
References in periodicals archive ?
I was at Golcar United last season but decided to leave, and we've put the Cask team together from lads who were not only at Golcar with me, but from other clubs like Lepton, Holme Valley Academicals and Brook Motors," added Haigh, who is nicely back in action after suffering ankle ligament damage in a pre-season friendly.
The resulting flavor of the whisky is so reminiscent of the liquid previously held in the cask, it takes the drinker's palate on a really remarkable journey.
It says cask ale is outperforming other drinks, and is forecast to make up 20% of on-trade beer sales by 2020.
As part of Cask Beer Week, Ross Holland and the team at Box Social Brewing are holding an open weekend and throwing open the doors to their brewery on September 24-27.
Burgundy casks, originally used for chardonnay, have brought their signature notes to Glen Moray 10 Year Old Chardonnay Cask Matured (Tesco, Sainsbury's, around PS25).
Hugh Sisson of Heavy Seas Beer has collaborated with Paul Pendyck of UK Brewing to develop a "caskerator" cask beer conversion kit available for purchase.
Glenfiddich's Select Cask and Reserve Cask are already in the stores, but the third expression, the Glenfiddich Vintage Cask, will be available from early 2014.
The Cask Report, published at the start of Cask Ale Week, said drinkers were choosing their beers more carefully.
This is only the second time that the company has released a Rare Cask edition; the first was in 2009 in China, and it had a strength of 43.
Finally, the team introduced a copy of the human CASK gene -- it is 80 percent identical to the fly CASK gene -- into the genome of a fly that completely lacked its own CASK gene and was therefore not usually able to remember.
Finally, they introduced a copy of the human CASK gene - it is 80 per cent identical to the fly CASK gene - into the genome of a fly that completely lacked its own CASK gene and was therefore not usually able to remember.
It was they who revealed this one utterly Rare Cask of LOUIS XIII that Nature has endowed with an excellence that is all its own.