CASK


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CASK

A gene on chromosome Xp11.4 that encodes a calcium/calmodulin-dependent serine protein kinase of the membrane-associated guanylate kinase (MAGUK) family, which are scaffold proteins located at synapses in the brain. CASK is involved in synaptic transmembrane protein anchoring and ion channel trafficking; contributes to neural development and regulating gene expression by interacting with the transcription factor TRB1; binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans; and may mediate a link between the extracellular matrix and the actin cytoskeleton with syndecan and the actin/spectrin-binding protein 4.1.
 
Molecular pathology
CASK mutations are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, as well as an X-linked form of mental retardation.
References in periodicals archive ?
We'd love to bring these casks by water from the distillery, but unfortunately the spur line is dry nowadays.
The system allows our staff to pull up a 3D layout of the warehouse at the touch of button so they can pinpoint the exact location of a cask in seconds.
Goldie Hawn and Tom Cruise have already staked their claim to special casks of what is described as "the whiskey of the century".
The new tests also show that soaking the steel casks at a low pH tends to cause cobalt to free itself from the surface and go into solution, Bennett says.
From remote islands of Scotland to small-batch distilleries in Japan, Cask and Kiln hopes to differentiate itself with its huge collection of interesting and rare bottles for whisky fans to explore.
Customers can choose to purchase their very own cask or select one of the rare bottled expressions from the online shop.
If someone stood next to a cask for one hour, they would receive about the same radiological dose as a dental X-ray," he said.
The Macallan Rare Cask encapsulates The Macallan's dedication and commitment to exceptional wood management, with far less than one percent of casks maturing at The Macallan distillery deemed fitting for the Rare Cask label by master whiskey maker Bob Dalgarno.
Our young manager Kieran Ellam, who has had to pack in because of a bad knee injury, is doing a cracking job," said Haigh, who confirmed Cask will be moving to the District League next season and probably with two teams.
Iron Maiden frontman Dickinson has penned the intoduction to the new Cask Report, the annual publication from Cask Marque on the strength of the real ale market.
Honey is very popular now, and bourbon cask staves can add depth and complexity," she says.