CARD9

CARD9

A gene on chromosome 9q34.3 that encodes a protein which activates NF-kappa-B by binding to BCL10 by a CARD–CARD interaction. It is highly expressed in the spleen, less so in the liver, placenta, lung, leukocytes and brain.

Molecular pathology
CARD9 mutations cause autosomal recessive chronic mucocutaneous candidiasis type 2.
References in periodicals archive ?
The Consortium is currently testing all novel loci in an independent set of 10,000 UC patients and a similar number of population controls to confirm these findings, but even the preliminary results provide "convincing evidence," he said, of associations to genes of biological significance to disease pathogenesis: TN-FRSF14, JAK2, CARD9 and others.
A mutation can interfere with one link in that chain, a molecule called CARD9, the researchers found.