RIPK2

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RIPK2

A gene on chromosome 8q21 that encodes a serine/threonine/tyrosine kinase which is intimately involved in modulating innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerise, and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes “Lys-63”-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein then recruits MAP3K7/TAK1 to IKBKG/NEMO, induces “Lys-63”-linked polyubiquitination of IKBKG/NEMO and activates IKBKB/IKKB.

In turn, NF-kappaB is released from NF-kappaB inhibitors and translocates to the nucleus, where it activates transcription of myriad genes involved in immune response, growth control or anti-apoptosis. It also plays a role during engagement of the T-cell receptor in promoting BCL10 phosphorylation and subsequent NF-kappaB activation.
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BOVESPA: CARD3 and PORTAL: CSURY), a leading independent provider in the Brazilian's Market of outsourced credit card administration services, will host today its 1Q08 results conference call.
BOVESPA: CARD3 and PORTAL: CSURY) today announces its results for the fourth quarter of 2007 (4Q07).
BOVESPA: CARD3 and PORTAL: CSURY) today announces its results for the second quarter of 2007 (2Q07) and the first half of 2007 (1H07).
BOVESPA: CARD3 and PORTAL: CSURY), a leading independent provider of outsourced credit card administration services, announces an updated schedule for the implementation of the Caixa Economica Federal Project ("Caixa Project"), comprising the migration of the entire Caixa Economica Federal ("CAIXA") card base to CSU CardSystem ("CSU").
BOVESPA: CARD3 and PORTAL: CSURY) announces today its fourth quarter results and the accumulated results for 2006 (4Q06 and 2006).
BOVESPA: CARD3 and PORTAL: CSURY), a leading independent provider of outsourced credit card administration services, announces the updated schedule for the implementation of the Caixa Economica Federal Project ("Caixa Project"), comprising the migration of the entire Caixa Economica Federal ("CAIXA") card base to CSU CardSystem ("CSU") and the implementation and management of card processing applications in CAIXA's technological facilities, followed by the provision of a full-service package, comprising card processing, call center, credit analysis and collection.
BOVESPA: CARD3 and PORTAL: CSURY) announces today its results for the third quarter of 2006 (3Q06).
BOVESPA: CARD3 e PORTAL: CSURY), a leading independent provider in the market of outsourced credit card administration services, announces that the financial statements for third quarter of 2006 (3Q06) will present the following figures relative to expenses and financial revenues for the 9 months ended September 30, 2006: