S100A4

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S100A4

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A4-encoded protein is thought to play a role in motility, invasion and tubulin polymerisation.
 
Molecular pathology
S100A4 rearrangements have been implicated in tumour metastasis.
References in periodicals archive ?
Finally, researchers at the Norwegian Radium Hospital and Hybridon scientists will collaborate on a search for an antisense compound to down regulate the expression of a cancer causing gene known as CAPL (calcium binding protein in placenta).
CAPL has several global big names in its client list including General Electric (GE), Daimler, Mitsubishi, Caterpillar, Siemens, Mahindra & Mahindra (M&M), Tata Cummins, Tata Motors, Case New Holland, John Deere, TAFE, L&T Enercon, Mahindra Navistar, JCB, Brakes India, Honeywell, Simpson plus Stork Print.
Table 75: CAPL - Wheatstone LNG Plant - Western Australia, Key Facts
Paul Stirling, manufacturing manager of the CAPL (Continuous Annealing Process Line) plant at Port Talbot, who is shown in the film added, 'I've never been in a film before, and probably never will again, but it was a lot of fun.
What incensed workers at the plant was that some senior staff pointed out that it was costing pounds 16,000 an hour while the CAPL line was not working.
The council's existing interests in CAPL result from work over the last 20 years to bring the building back into use and operate it as a unique hotel.
To date, nearly 2,000 children have been tested using various iterations of the CAPL.
The CAPL project will be carried out between July and December 2012 to coincide with the BOS Plant project, as well as with the pounds 185m project to rebuild Port Talbot's Blast Furnace No 4, announced in August last year.
Ziment's chief methodologist, John Tapper, said that recent software developments and the company's use of the latest data mining and modeling techniques such as CAPL regression, neural networks and CART analysis now do the complex calculations that give market researchers an edge.
The contract is for the purchase of fuel and heating oil for the control group composed of the CAPL and the Municipalities of Cannes, Mougins and Theoule-sur-Mer and the CCAS of Cannes.