S100A2

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S100A2

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A2-encoded protein is thought to have tumour suppressor activity.

Molecular pathology
Gene rearrangements and altered expression of S100A2 have been implicated in breast cancer.