CA.1aj.9

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CA.1aj.9

A gene on chromosome 9p12 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate in various biological processes, including respiration, calcification, maintaining acid-base balance and bone resorption, as well as producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. CA9 is a transmembrane protein and the only known tumour-associated carbonic anhydrase isoenzyme, and may be involved in cell proliferation and transformation.

Molecular pathology
CA9 is expressed in all clear-cell type renal cell carcinomas, but is not expressed in normal kidney or most other normal tissues.
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Of the 21 IHCs, 15 will be available immediately and include: PD1, PD-L1, MGMT, MET, TOP1, PTEN, AR, CAIX, ER, HER2, IDO, PR, TRKA, TRKB and TUBB3.
Contract notice: CAIX Preclinical toxicity project.
The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.
5) One study suggests that a low amount of CAIX in the serum of a RCC patient is not only associated with a poor prognosis, but that these patients will not respond well to cytokine therapy such as Interleukin 2.
Diagnostic Use of PAX8, CAIX, TTF-1, and TGB in metastatic renal cell carcinoma of the thyroid.
April 10, 2012 /PRNewswire/ -- GeneTex, a leading manufacturer of antibodies, is pleased to announce that they will be launching a new antibody against CAIX, a marker of hypoxia that shows great promise for cancer research.
28) Level of immunohistochemical expression of CAIX was not predictive of OS.
cMet, IGFR-1, FAP-alpha, PSCA, endosialin, CAIX or Her2/neu"
Other biomarkers with encouraging but less robust data on their potential prognostic role in BC include tumor microenvironment markers, such as cell adhesion markers E cadherin and N cadherin, (20,118) and angiogenesis modulators such as HIF1a, HIF-2, vascular endothelial growth factor (VEGF), CAIX, and thrombospondin-1.
HIF-1alpha is responsible for the expression of a number of growth factors including VEGF, PDGF, TGF, erythropoietin, Glut-1, PAI-1 and CAIX, which can promote angiogenesis.
87) Among them, CAIX is one of the most important molecular markers for RCC.
Additionally, diffuse membranous staining for CAIX is present, reflecting inactivation of the von Hippel-Landau (VHL) gene and constitutive activation of the hypoxia-inducible factor (HIF) pathway (see below).