S100A9

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S100A9

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. S100A9 has antimicrobial activity against bacteria and fungi and provides resistance to invasion by pathogenic bacteria, and it upregulates transcription of genes under the control of NF-kappa-B; it is linked to the endotoxic shock response to bacterial lipopolysaccharide. S100A9 promotes tubulin polymerisation and macrophage and granulocyte migration and infiltration into wound sites; it is a pro-inflammatory mediator and upregulates IL8 release and cell surface expression of ICAM1. Extracellular S100A9 (calprotectin) binds to target cells and promotes apoptosis.
 
Molecular pathology
Altered expression of S100A9 is linked to cystic fibrosis.
References in periodicals archive ?
To measure quality, we calculated for each hospital a mortality Z-score based on its number of CABG patients and the difference between its predicted and actual number of CAGB patient deaths.
Desert Regional Medical Center, Palm Springs - Angioplasty*, CAGB, Cardiac Catheterization, Caesarean Section, Laparoscopic Gallbladder Removal, Gastric Bypass, Heart Attack, Total Hip Replacement*, Total Abdominal Hysterectomy, Total Knee Replacement*, Adult Pneumonia and Stroke
Main features: the object of the contract is on assistance to the CAGB, the City of Besanon and the CCAS, throughout the recruitment process, except for: -The definition of need and drafting the profile that will be already carried out, -The distribution profile on the media: websites the CAGB, of the city of Besanon or CCAS, Cap employment and labor exchange CNFPT, which will be conducted by the Division of Human Resources for the 3 entities
Framework Agreement for the maintenance, major repairs and refurbishments in various buildings and properties in the city of Besancon, the CAGB and CCAS.
Supply, servicing and maintenance of poles and bus shelters across the transport CAGB the network.