CACNB4

(redirected from CAB4)

CACNB4

A gene on chromosome 2q22-q23 that encodes a beta subunit of a voltage-dependent calcium channel, which plays a regulatory role in calcium channel function by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling alpha-1 subunit membrane targeting.

Molecular pathology
CACNB4 mutations have been associated with idiopathic generalised epilepsy and juvenile myoclonic epilepsy.
References in periodicals archive ?
10 million of additional counterpart financing and includes a restructuring of the CAB4 project involving: (a) changes to the project components; (b) extension of the CAB4 project closing date to be coterminus with the closing date of the AF; (c) revisions to the Results Framework; and (d) application of the most recent procurement guidelines, dated January 2011 and revised July 2014.
10 million of additional counterpart financing and includes a restructuring of the CAB4 project involving: (a) changes to the project components; (b) extension of the CAB4 project closing date to be coterminous with the closing date of the AF; (c) revisions to the Results Framework; and (d) application of the most recent procurement guidelines, dated January 2011 and revised July 2014.