MUC16

(redirected from CA125)

MUC16

A gene on chromosome 19p13.2 which encodes a protein that provides a protective lubricating barrier against particles and infectious agents at mucosal surfaces. It is more commonly known as CA125, and is a highly characteristic marker of ovarian carcinomas.
References in periodicals archive ?
announced today that it entered into a collaborative research agreement with University of Wisconsin-Madison (UW-Madison) to elucidate the immunosuppressive effects of the CA125 tumor antigen on the investigational monoclonal antibody farletuzumab.
OncoQuest's technology platform includes a panel of tumor antigen specific monoclonal immunoglobulins including CA125, MUC1, PSA and Her2/neu; and the application of combinatorial immunotherapy to enhance tumor specific immunity and clinical outcome.
In this case presentation, an old diabetic and newly-diagnosed cirrhotic woman was reported who presented with abdominopelvic mass, ascites, and elevated CA125.
The new blood test developed by scientists, which tracks levels of a protein linked to the disease, is twice as accurate as traditional measures that use a fixed cut-off point for the protein, called CA125.
These tests include T3, T4,TSH, TFT, FSH, LH, PROLACTIN, PROGESTERON, PSA, CEA, CA125, BETA HCG, ALFAFETO, PROTEIN, FERRITIN, VIT B12, FOLIC ACID.
Now Mary, 58, is calling for GPs to routinely use a simple blood test - CA125 - to help end the misery caused by the frequent misdiagnosis of the deadly disease.
False biomarker discovery due to reactivity of a commercial ELISA for CUZD1 with cancer antigen CA125.
The symptom index, when used in combination with CA125, improves the sensitivity over CA125 alone.
CUZD1 and CA125 share no molecular similarities that explain this error.
When they used a mathematical model to combine the detection of IDH1 with the detection of existing markers CEA, Cyfra21-1, and CA125, the sensitivity increased to 86 percent.
Researchers said that the new biomarker helps detect stage 1 lung cancer easily and accurately as the protein is more sensitive (86 percent higher) than the currently available biomarkers used to diagnose lung cancer - CEA, Cyfra21-1 and CA125.