C5

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C5

A diagnostic category based on the NHSBSP guidelines for reporting fine needle aspiration cytology of breast lesions. C5 aspirates are adequate and contain cells with features that are frankly malignant; some centres divide them into C5a (carcinoma in situ) and C5b (invasive carcinoma). The smears are usually highly cellular with single or dissociated clusters of malignant cells, with increased nuclear:cytoplasmic ratio, markedly pleomorphic cells with hyperchromatic nuclei, prominent nucleoli, irregular nuclear membrane and chromatin, and often a necrotic background.

complement deficiency

A state in which any of the complement proteins is subnormal
Complement deficiencies–associated disorders
C1
C1r    SLE, renal disease, repeated infections
C1s    SLE
C2    SLE, vasculitis, membranoproliferative glomerulonephritis, dermatomyositis
C3 Repeated infections
C4 SLE
C5 SLE, gonococcal disease
C6 Relapsing meningococcal meningitis, gonococcal infection
C7 Raynaud's disease, chronic renal disease, gonococcal infection
C8 SLE, gonococcal infection