ADAMTSab1

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ADAMTSab1

An ADAMTS family protease encoded by ADAMTS1 on chromosome 21q21.2, which is antiangiogenic (ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, thrombospondin-1, or endostatin). ADAMTS1 is associated with acute inflammation and various inflammatory processes and with the development of cancer cachexia. ADAMTS1 expression is induced by IL1 and appears to be necessary for normal growth, fertility (it is up-regulated by progesterone during ovulation, and may play a critical role in follicular rupture), organogenesis and organ function. ADAMTS1 activity is blocked by some metalloprotease inhibitors, including TIMP-2 and TIMP-3. Thrombospondin proteolysis is decreased or absent in ADAMTS1 knock-out mice and associated with delayed wound closure and increased angiogenesis.
References in periodicals archive ?
363 Insignificant Difference Pairs C1-C4 C3-C5 in Term of Mean Value Major axis Mean Value 9.
The second most insignificant difference pairs in term of mean values were C3-C5 pair for rectangular aspect ratio and minor axis length and C2-C4 pair for minor axis length and aspect ratio.
We've had to increase the mud weights considerably as we drill deeper, and we continue to see rising mudlog gas readings, including the oil-indicative C3-C5 factions, which is encouraging.