C3 convertase


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C3 convertase

(1) Classical-complement-pathway C3/C5 convertase (often shortened to C3/C5 convertase), EC 3.4.21.43. 
(2) Alternative-complement-pathway C3/C5 convertase (also known as properdin Factor B), EC 3.4.21.47.
References in periodicals archive ?
Researchers at the University of Pennsylvania School of Medicine, in collaboration with colleagues at Utrecht University in the Netherlands, have determined the structure of C3 convertase and of the C3b fragment in complex with factor H.
When complement proteins are triggered into action by a microbe, the proteins ultimately form a complex enzyme called C3 convertase, which triggers a cascade of immune and inflammatory reactions.
According to the Company, DDD is an ultra-rare, progressive kidney disease that results in kidney failure in the majority of affected individuals, and is caused by dysregulation of the C3 Convertase, a major early component of the alternative pathway of complement.