C3


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C3

A diagnostic category based on the NHSBSP guidelines for reporting FNAC (fine needle aspiration cytology) of breast lesions. C3s have most of the characteristics described in C2s, but also have features not usually present in benign smears and have one or more of the following features:
(1) Crowded, enlarged nuclei with overlapping in three-dimensional groups or sheets;
(2) Loss of cellular cohesion;
(3) Nuclear pleomorphism;
(4) Chromatin clumping.
 
C3 cellularity may be normal or increased and large bare nuclei may be seen, as well as nuclear pleomorphism and dissociation.

Examples, C3
Epithelial hyperplasia with or without atypia, fibroadenoma/fibroadenomatoid change, gynaecomastia, papilloma, hormonal changes, radial scar, atypical apocrine lesion, columnar cell change, lobular lesions (e.g., atypical lobular hyperplasi), certain carcinomas (e.g., tubular carcinoma, cribriform carcinoma).

complement deficiency

A state in which any of the complement proteins is subnormal
Complement deficiencies–associated disorders
C1
C1r    SLE, renal disease, repeated infections
C1s    SLE
C2    SLE, vasculitis, membranoproliferative glomerulonephritis, dermatomyositis
C3 Repeated infections
C4 SLE
C5 SLE, gonococcal disease
C6 Relapsing meningococcal meningitis, gonococcal infection
C7 Raynaud's disease, chronic renal disease, gonococcal infection
C8 SLE, gonococcal infection

C3

The most abundant and functionally diverse component of the complement system.C3 has two main allotypes F (fast) and S (slow). In kidney transplant patients it has been found that C3 S/S recipients have a better long-term outcome when grafted with a C3 F/F or a C3 F/S/ kidney than with a C3 S/SF kidney.

C3

the third component of complement; a β protein. Split into two fragments, C3a and C3b, by C3 convertase which is triggered via the classical or alternative pathway of complement activation. An inherited deficiency occurs in Brittany spaniels and very low serum levels occur in some Finnish-Landrace lambs. See also complement.