C225

C225

A chimeric IgG antibody with a strong binding affinity for epidermal growth factor (EGF) receptor, which blocks ligand—EGF, TGF α, etc.—binding and inhibits cell proliferation. C225 made it through to Phase III trials, during which time it was renamed cetuximab (Erbitux), and has proved to be a blockbuster cancer drug for head and neck cancer, colorectal and other cancers.
References in periodicals archive ?
Pole Positions for the C1, C2 and C225 categories were determined by a draw organised by race officials in the pit area.
Paclitaxelenhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma.
Harris, Report on Public Buildings, 1824, ML C225, p.
Using human colorectal cancer tumour xenografts, the activity of C225 and irinotecan given either alone or in combination was evaluated.
Model C225 is has a "total reactive dig" pre-saw, which eliminates cutting.
Dynamit Nobel-RWS found instant success last year with their C225 air pistol series.
Andrew Odlyzko, Information Sciences Research Center, AT&T Labs--Research, Room C225, 180 Park Ave.
Combined modality therapy of A431 human epidermoid cancer using anti-EGFr antibody C225 and radiation.
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.
patents in its production of Erbitux(R), also known as C225.
21, 73-80, 2002) and targeted anticancer agents such as C225, a monoclonal antibody to epidermal growth factor receptor (Clin.