C225

C225

A chimeric IgG antibody with a strong binding affinity for epidermal growth factor (EGF) receptor, which blocks ligand—EGF, TGF α, etc.—binding and inhibits cell proliferation. C225 made it through to Phase III trials, during which time it was renamed cetuximab (Erbitux), and has proved to be a blockbuster cancer drug for head and neck cancer, colorectal and other cancers.
References in periodicals archive ?
Pole Positions for the C1, C2 and C225 categories were determined by a draw organised by race officials in the pit area.
Huang SM, Bock JM, Harari PM (1999) Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck.
Paclitaxelenhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma.
Earlier summaries of in vivo studies on HiFi colon adenocarcinomas, at the Sloan Kettering Cancer Center of New York, report that these tumor cells display the features of apoptosis following exposure to the anti-EGFr humanto-murine chimeric MAb C225 (13).
Although several mAb drugs exist, only cetuximab, also known as C225 or Erbitux, has received U.
Harris, Report on Public Buildings, 1824, ML C225, p.
Using human colorectal cancer tumour xenografts, the activity of C225 and irinotecan given either alone or in combination was evaluated.
Corresponding author: Garrett O'Keefe, Professor and Chair, Department of Journalism and Technical Communication, Colorado State University, C225 Clark Bldg, Fort Collins, CO 80526, Phone: 970-491-3703, Fax: 970-491-2908, Email:gjokeefe@lamar.
edu>; Cathy Romaniello, MPH, RD, Public Health Nutritionist, Center for Human Nutrition, University of Colorado Health Sciences Center, Box C225, 4200 E.
Model C225 is has a "total reactive dig" pre-saw, which eliminates cutting.
Dynamit Nobel-RWS found instant success last year with their C225 air pistol series.