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Noted for dominant or co-dominant immunofluorescence staining for Clq on a renal biopsy, C1q nephropathy appears to be on the spectrum of MCNS/FSGS.
Known examples of glomerulonephritis where segmental sclerosis is commonly part of the disease entity are immunoglobulin (Ig) A nephropathy, IgM nephropathy, and C1q nephropathy.
More controversial is the case of IgM or C1q nephropathy.