NPPC

(redirected from C-type natriuretic peptide)
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NPPC

A gene on chromosome 2q24-qter that encodes a member of the natriuretic peptide family. The secreted NPPB protein product binds to NPR2 and NPR3 receptors; it is involved in natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and plays a key role in cardiovascular homeostasis. NPPC also plays a role in endochondral ossification by regulating cartilaginous growth plate chondrocyte proliferation and differentiation.
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C-type natriuretic peptide and guanylyl cyclase B receptor.
Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP).
Myocardial production of C-type natriuretic peptide in chronic heart failure.
Seminal plasma factors that cause large elevations in cellular cyclic GMP are C-type natriuretic peptides.
77-108]), C-type natriuretic peptide, rat adrenomedullin, and human endothelin-1] were <0.
Hydrolysis of human and pig brain natriuretic peptides, urodilatin, C-type natriuretic peptide and some C-receptor ligands by endopeptidase-24.
C-type natriuretic peptide expression in human coronary atherosclerotic lesions.
Some specific topics covered include muscle involvement and IGF-1 signaling in genetic disorders, mitochondrial encephalomyopathies and related syndromes, double diabetes in youth, C-type natriuretic peptide and overgrowth, and the role of transcription factors in midline central nervous system and pituitary defects.
Along with A- and C-type natriuretic peptides, BNP participates in the maintenance of cardiorenal function by increasing sodium excretion and reducing cardiac load and blood pressure (3, 4).
Physiologic and pathologic states leading to volume expansion and/or increased tension on cardiac myocytes lead to up-regulation of signals for the production and secretion of cardiac natriuretic prohormones, including A-, B-, and C-type natriuretic peptides (1).