CD117

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CD117

a type I transmembrane protein present on hemopoietic progenitors, mast cells, melanocytes, spermatogonia, oocytes, and some natural killer cells; assists in signal transduction to transfected cell lines; expressed in colon carcinomas.
References in periodicals archive ?
Targeted therapies for patients with advanced disease may be helped by the identification of the MYB-NFIB gene fusion, among others, since other targets, such as proto-oncogene C-kit, are not mutated.
On immunohistochemical staining, the tumor cells stained intensely and diffusely for calretinin (Fig 5), whereas there was no reaction for placental alkaline phosphatase and c-Kit expression.
Examples of oncology diagnostic tests that comprise the new standard of care include ER and HER2 in breast cancer, bcr-abl in chronic myeloid leukemia, c-Kit in gastrointestinal stromal tumors, BRAF in melanoma, and EGFR and ALK in lung cancers.
Sammons Cancer Center (Baylor Sammons) to assess the thoroughness of initial diagnostic evaluations based on current guidelines at our cancer center, including up-to-date molecular analyses for mutations in the NPM1, CEBPA, FLT3, and C-KIT genes.
Lenvatinib, discovered and developed by Eisai, is an orally active, selective inhibitor of receptor tyrosine kinases (RTKs) with a novel binding mode, including KDR (VEGFR-2), Flt-1 (VEGFR-1), RET, FGFR1, PDGFR-Beta and c-kit, involved in angiogenesis and tumor proliferation.
4) The defining feature of these tumors is the expression of c-KIT (CD117), a tyrosine kinase growth factor receptor.
These cells stained strongly with a c-KIT immunohistochemical stain, confirming the morphologic impression of mast cells (MCs; Figure, C).
An altered bone and mineral metabolism, a reduction of testosterone, and gynecomastia are the other defined side effects of imatinib mesylate, which were attributed to the PDGF-R and c-KIT inhibition in normal cells by imatinib mesylate.
The finding that Cajal cells express c-kit (CD117), a tyrosine kinase, is a considerable development.
The investigators harvested the CSCs, referred to as "c-kit positive" cells because they express the c-kit protein on their surface, from 33 patients during coronary artery bypass surgery.
5D) and negative for desmin, calreti-nin, S-100, smooth muscle actin, C-kit, confirming the diagnosis of angiosarcoma.
5] increases EPC levels in the bone marrow by preventing their mobilization to the peripheral blood via inhibition of signaling events triggered by VEGF-receptor stimulation that are upstream of c-kit activation.