CD117

(redirected from C-kit)

CD117

a type I transmembrane protein present on hemopoietic progenitors, mast cells, melanocytes, spermatogonia, oocytes, and some natural killer cells; assists in signal transduction to transfected cell lines; expressed in colon carcinomas.
References in periodicals archive ?
Our results also indicated that c-kit expression was higher in the white cashmere goat than in the black goat, and this significant difference was detected by q-PCR and western blotting.
Background and Objective: To evaluate usefulness of immunohistochemical marker C-kit (CD117) in differentiating Adenoid cystic carcinoma (AdCC) from Polymorphous low-grade adenocarcinoma (PLGA) in patients of salivary gland carcinomas.
The deposition of iron into LSK cells (Lin-Sca-1 + c-kit +) was assessed using hematoxylin and eosin (HE) staining and Perls' iron staining.
Myelosuppressive effects are also noted, such as anemia, thrombocytopenia, and leukopenia, and are presumably mediated through c-kit inhibition.
15 c-Kit mutations should be included in risk stratification.
Chromophobe renal cell carcinomas are typically c-kit (CD117)-positive and variably positive for cytokeratin 7 (CK7), whereas oncocytomas are typically positive for c-kit (CD117) and show very focal scattered positivity for CK7.
Recognition of transmembrane tyrosine kinase receptor, c-kit through conventional immunohistochemistry has been evolved as valuable adjunct to routine light microscopy for highlighting the ICCs distribution.
Aims: To assess the rate of C-KIT positivity and its effect on survival of surgically treated sinonasal malignant melanoma patients with other histopathological biomarkers and clinical features.
Furthermore, imatinib, as a tyrosine kinase inhibitor for c-KIT or PDGFRA, is extensively used in treating GST.
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Recently, Oct-4 and c-kit were reported to be experessed in buffalo testis and spermatogonail stem cells (Xie et al.
A set of mutations termed "internal tandem duplications" (ITD) affecting the exon 11 of the c-kit gene has been associated with the development of some mast cell tumors in dogs (LONDON et al.