jun

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JUN

A gene on chromosome 1p32-p31 that is the putative transforming gene of avian sarcoma virus 17, which interacts directly with specific target DNA sequences to regulate gene expression.

Molecular pathology
JUN maps to a chromosome region involved in both translocations and deletions in cancer.

jun

(joon)
A family of oncogenes that can transform some normal cells (e.g., rat embryo cells) into cancer cells. All members of this family can bind to activating protein-1 (AP-1) sites and to specific DNA sequences. See: oncogene; transformation
References in periodicals archive ?
Dose-dependent effect of ginaton treatment on activation and expression of c-Jun induced by reperfusion after renal ischemia
impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver.
Down-regulation of c-jun N-terminal kinase-activator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells.
We report here that, using a perfused rabbit lung model that is devoid of blood cells, ROFA induces phosphorylation and functional activation of the transcription factors c-Jun, ATF-2, CREB, and NF[kappa]B in lung cells.
Differential c-jun expression in response to tumor promoters in JB6 cells sensitive or resistant to neoplastic transformation.
Transcriptional regulation of c-Jun during inhibtion by selenite of methylmercury-induced apoptosis of rat C6 glioma cell.
1 ctrl Stress genes Metallothionein I 2,671 1,726 254 354 246 126 Metallothionein II 6,805 2,077 368 423 283 115 Hsp 105 2,276 210 120 119 117 107 Hsp 25 3,720 450 80 38 57 98 Hsp 86 1,329 493 113 105 112 119 GFIP 1,089 105 141 116 103 101 chop 10 387 132 95 90 98 81 c-jun 743 95 96 87 99 98 jun-b 327 165 115 97 100 61 Xenobotic metabolizing enzymes Cyp2F2 24 142 116 140 149 122 CYP3A11 30 125 152 131 161 99 Methyl TX 111 34 94 109 104 110 96 AcetylTx 424 240 116 107 133 117 Cyp1a2 Cyp1a1 Cyp2a BaP(mg/kg) Gene 100 10 1 0.
AM-111, which is being evaluated in two Phase 3 clinical trials, contains the synthetic peptide brimapitide (also called D-JNKI-1, D-stereoisomer of c-Jun N-terminal Kinase Inhibitor 1), a cell-penetrating inhibitor of the JNK stress kinase.
In addition, according to the researchers, "AP-1 consists of both Fos and Jun genes' family members, which include c-Fos and c-Jun.