HES6

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HES6

A gene on chromosome 2q37.3 that encodes a transcription repressor which, while not binding DNA, suppresses HES1-mediated N-box-dependent transcriptional repression and the binding of HES1 to E-box sequences. HES6 also suppresses HES1-mediated inhibition of the ASCL1/MASH1 and TCF3/E47 heterodimer, allowing ASCL1 and TCF3 to upregulate transcription. It promotes cell differentiation.