Caenorhabditis elegans

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Caenorhabditis elegans

(sē″nō-răb-dīt′ĭs ĕl′ă-gănz, -găns)
A roundworm, about 1 mm long. It is the first multicellular organism for which the full genome was sequenced. Its cells are used in studies of the molecular basis of development, aging, and fat metabolism.
References in periodicals archive ?
In a high glucose environment, C elegans treated with rooibos extract exhibited an extended lifespan.
In this study, we investigated whether rooibos aqueous extract can protect C elegans against oxidative stress caused by the pro-oxidant juglone or a high glucose environment.
According to the report, C elegans was the first multi-cellular organism to have its genetic structure completely mapped and many of its 20,000 genes perform the same functions as those in humans.
C elegans often feed on decaying fruit and vegetable matter.
Although neurodegeneration can easily be visualized in C elegans by labeling neurons with fluorescent markers such as FITC (fluorescein isothiocyanate), DiI (l,l'-dioctadecyl-3,3,3',3',-tetramethylindo-carbocyanine perchlorate), DiO (3,3'-diocta-decyloxa carbocyanine perchlorate), and DiD (1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indodicarbocyanine perchlorate) (Tong and Burglin 2010), the direct role of adiposity on neurodegeneration has not been explored to date.
When bathed in Prozac, C elegans responds in two obvious ways.
Marc Vidal, whose laboratory at the Dana Farber Cancer Institute recently used the technology to create a complete gene collection for C elegans, commented on the new architecture: "Our goal was to utilize this collection we created with Gateway(R) Technology across the spectrum of research involving C elegans.
elegans remains uncertain, because one study has demonstrated that long telomeres promote increased lifespans in C elegans (Joeng et al.
The same phenomenon explains the rapid elongation of C elegans, says Austin.
we can figure out what they're doing in C elegans and apply that to a whole myriad of human genetic issues," says Waterston.
Now, David Zarkower of the University of Minnesota Medical School in Minneapolis and his coworkers have identified a gene called mab-3 that governs aspects of male development for C elegans, which is either male or hermaphroditic.
But in C elegans at least, GABA sometimes excites nerve cells, McIntire and his coauthors report in the July 22 NATURE.