butyrophenones


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Related to butyrophenones: haloperidol, Phenothiazines, Thioxanthenes

butyrophenones

A group of phenothiazine derivative drugs used in the treatment of SCHIZOPHRENIA. The group includes HALOPERIDOL, triperidol and benperidol.
References in periodicals archive ?
Butyrophenones create serious risk of oculogyric crisis and although these dystonic reactions are reversible, they irritate the patient substantially.
If psychiatry needs a good, immediate fix, it would be in the development and approval of new chemicals that are both better tolerated than the butyrophenones and more affordable than atypical antipsychotics.
The most common drug classes for single-drug incidents were phenothiazines 84, tricyclic antidepressants 83, butyrophenones 74, paraaminophenols 62, benzodiazepines 46, carbamazepines 36, iron compounds 35, methoxybenzamides 27 and xanthines 27.
Dopamine receptors are located in the chemoreceptor trigger zone and dopamine receptor antagonists primarily affect this area; however, high doses of dopamine receptor blockades result in extrapyramidal reactions, disorientation, and sedation, which limit the clinical use of such agents, including phenothiazines and butyrophenones (droperidol and haloperidol) (8).
Anti-emetics The phenothiazines, butyrophenones (such as droperidol) and metoclopramide, have all been known to cause drug induced PD, and can aggravate and intensify the patient's symptoms (Burton et al 2004).
Moreover, he was editor of important books of clinical psychopharmacology such as the Clinical handbook of psychopharmacology (Science House, New York, 1970) and Butyrophenones in psychiatry (Raven Press, New York, 1972).
Two major groups of neuroleptics are the phenothiazines and the butyrophenones.
TABLE Physiologic, pharmacologic, and pathologic causes of an elevated serum prolactin level (1) PHYSIOLOGIC Pregnancy Ectopic pregnancy Lactation Nipple stimulation Stress Sleep disorder PHARMACOLGIC Dopamine receptor antagonists: phenothiazines, butyrophenones, thioxanthene, risperidone, metoclopramide, sulpiride, pimozide Dopamine-depleting agents: [alpha]-methyldopa, reserpine Hormones: estrogens, antiandrogens Others: danazol, isoniazid, verapamil, cyproheptadine, opiates, H2-blockers (cimetidine), cocaine and marijuana, tricyclic antidepressants PATHOLOGIC Acromegaly Alcoholic cirrhosis Chest wall trauma or tumor Herpes zoster Hypothalamic and pituitary stalk disease Hypothyroidism Pituitary tumors: prolactinomas, adenomas Polycystic ovarian syndrome Renal failure Sarcoidosis
Selected butyrophenones used after surgery to address postoperative nausea and vomiting include droperidol, which he referred to as "the Bendectin of anesthesiologists.
In the first, phenothiazines and butyrophenones may form insoluble precipitates when given concurrently with caffeine.
Phenothiazines, butyrophenones, and metoclopramide (Reglan) have the most direct effect on blocking the pathway between the center in the medulla that controls vomiting and the chemoreceptor trigger zone.