Burkitt's lymphoma

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Burkitt's lymphoma

 [berk´its]
a form of undifferentiated lymphoma, usually found in central Africa but also reported from other areas, and manifested most often as a large bone-destroying lesion in the jaw or as an abdominal mass. The epstein-barr virus (EB virus), a herpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. Called also African lymphoma and Burkitt's tumor.

Burkitt's lymphoma

[bur′kits]
Etymology: Denis P. Burkitt, English surgeon in Africa, b. 1911
a malignant neoplasm composed of undifferentiated lymphoreticular cells that form a large osteolytic lesion in the jaw or, in children, an abdominal mass. The tumor, which is seen chiefly in Central Africa, is characteristically a gray-white mass sometimes containing areas of hemorrhage and necrosis. Central nervous system involvement often occurs, and other organs may be affected. The Epstein-Barr virus (EBV), a herpesvirus, is associated with this lymphoma however, most non-African cases are EBV negative. Chemotherapy can often cure the disease. Also called African lymphoma, Burkitt's tumor.

Burkitt's lymphoma

A tumour of B lymphocytes occurring mainly in Central Africa and New Guinea and associated with the Epstein Barr virus, spread by insects. It affects mainly the lower and upper jaws of young children but can affect most parts of the body. Burkitt's lymphoma was one of the first human tumours to be shown to be caused in this way. The tumour commonly spreads to the abdomen where large secondary masses may form, affecting the bowel. Immunosuppressive chemotherapy with cyclophosphamide or METHOTREXATE is apparently curative in 80% of early cases and about 40% of those with advanced, widespread disease. (Dennis Parsons Burkitt, 1911–93, English medical researcher, bran apostle, and Fellow of the Royal Society).

Burkitt's lymphoma

a common cancer of African children, producing tumours of the jaw and facial bones and affecting the spleen and lymph nodes. It is caused by the Epstein-Barr virus.

Burkitt's lymphoma,

n.pr malignant undifferentiated lymphoma usually found in central African children, marked by an enlarged mandible or by a growth in the retroperitoneal area; has been linked to the Epstein-Barr virus.
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Burkitt's lymphoma.

Burkitt's lymphoma, Burkitt's tumor

a form of undifferentiated malignant lymphoma in humans and primates, especially marmosets and some gibbons. Usually found in central Africa, but also reported from other areas, and manifested most often as a large osteolytic lesion in the jaw or as an abdominal mass; called also African lymphoma.
The Epstein-Barr virus (EB virus), a gammaherpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. The same virus causes the relatively benign, though debilitating, disease infectious mononucleosis (glandular fever) of humans.