Burkitt's lymphoma


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Burkitt's lymphoma

 [berk´its]
a form of undifferentiated lymphoma, usually found in central Africa but also reported from other areas, and manifested most often as a large bone-destroying lesion in the jaw or as an abdominal mass. The epstein-barr virus (EB virus), a herpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. Called also African lymphoma and Burkitt's tumor.

Burkitt's lymphoma

[bur′kits]
Etymology: Denis P. Burkitt, English surgeon in Africa, b. 1911
a malignant neoplasm composed of undifferentiated lymphoreticular cells that form a large osteolytic lesion in the jaw or, in children, an abdominal mass. The tumor, which is seen chiefly in Central Africa, is characteristically a gray-white mass sometimes containing areas of hemorrhage and necrosis. Central nervous system involvement often occurs, and other organs may be affected. The Epstein-Barr virus (EBV), a herpesvirus, is associated with this lymphoma however, most non-African cases are EBV negative. Chemotherapy can often cure the disease. Also called African lymphoma, Burkitt's tumor.

Burkitt's lymphoma

A tumour of B lymphocytes occurring mainly in Central Africa and New Guinea and associated with the Epstein Barr virus, spread by insects. It affects mainly the lower and upper jaws of young children but can affect most parts of the body. Burkitt's lymphoma was one of the first human tumours to be shown to be caused in this way. The tumour commonly spreads to the abdomen where large secondary masses may form, affecting the bowel. Immunosuppressive chemotherapy with cyclophosphamide or METHOTREXATE is apparently curative in 80% of early cases and about 40% of those with advanced, widespread disease. (Dennis Parsons Burkitt, 1911–93, English medical researcher, bran apostle, and Fellow of the Royal Society).

Burkitt's lymphoma

a common cancer of African children, producing tumours of the jaw and facial bones and affecting the spleen and lymph nodes. It is caused by the Epstein-Barr virus.

Burkitt's lymphoma,

n.pr malignant undifferentiated lymphoma usually found in central African children, marked by an enlarged mandible or by a growth in the retroperitoneal area; has been linked to the Epstein-Barr virus.
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Burkitt's lymphoma.

Burkitt's lymphoma, Burkitt's tumor

a form of undifferentiated malignant lymphoma in humans and primates, especially marmosets and some gibbons. Usually found in central Africa, but also reported from other areas, and manifested most often as a large osteolytic lesion in the jaw or as an abdominal mass; called also African lymphoma.
The Epstein-Barr virus (EB virus), a gammaherpesvirus, has been isolated from Burkitt's lymphoma cells in culture, and has been implicated as a causative agent. The same virus causes the relatively benign, though debilitating, disease infectious mononucleosis (glandular fever) of humans.
References in periodicals archive ?
Plasma cell infiltrates Florid plasma cell expansion in lymph nodes, tissues and bone marrow with polyclonal hypergammaglobulinemia HHV8-associated pathologies MCD MCD with so-called microlymphoma MCD with lymphoma MCD with Kaposi's sarcoma MCD with HHV8 associated haemophagocytic syndrome Lymphomas specifically occurring in HIV-positive patients Plasmablostic lymphoma Primary effusion lymphoma--classical and 'solid' forms Lymphomas orising in MCD Lymphomas occurring In other immunodeficient states Lesions similar to polymorphic post-transplant lymphoproliferative disorder Lymphomas also occurring In immune competent patients Classical Hodgkin's lymphoma Burkitt's lymphoma Diffuse large B-cell lymphoma MCD, multicentric Castleman's disease.
Burkitt's lymphoma cells, which have voracious appetites, commandeer the process to accommodate their growth needs, says Kastan.
In 2001, the REAL classification system was updated by the World Health Organization, which classified Burkitt's lymphoma together with Burkitt's leukemia as a mature (peripheral) B cell neoplasm.
Denis explained, "What at the time appeared to be a casual medical consultation eventually was to lead, after years of research, to the identification and understanding of the form of cancer now known as Burkitt's lymphoma.
The MYC gene is translocated in all patients with Burkitt's lymphoma and in a significant number of patients with multiple myeloma or a form of lymphoma known as diffuse large B-cell lymphoma.
Abnormal MYC activity is believed to be a key factor in breast, lung, colon, hematologic and other cancers, including Burkitt's lymphoma, a fast-growing cancer that tends to strike children.
Football-mad Cole Breadner, 10, from Prenton, died in February, just 16 weeks after he was diagnosed with Burkitt's lymphoma, a rare and aggressive form of the disease.
Jake Whitefield was diagnosed with Burkitt's Lymphoma six weeks ago, after doctors discovered agonising stomach pains weren't down to a sporting injury but, in fact, an aggressive tumour which was forcing its way through the 11-year-old's bowel.
A survey carried out among children (<18 years of age) over the decade January 1995--December 2004 showed that Burkitt's lymphoma was the most common malignancy (73.
Marathon man 'Blind Dave' Heeley, from West Bromwich, and a team of firefighters led by Adam Joyce, who has battled past Burkitt's Lymphoma, a rare form of Leukaemia, also took part - wearing their full uniform.
Burkitt's lymphoma (or Burkitt's tumour, or malignant lymphoma Burkitt's type) is a cancer of B lymphocytes, named after Denis Parsons Burkitt, a surgeon who first described the disease in 1956 while working in equatorial Africa.