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buffalo hump

   Also found in: Wikipedia 0.02 sec.
buffalo hump,
an accumulation of fat on the back of the neck associated with the prolonged use of large doses of glucocorticoids or the hypersecretion of cortisol caused by Cushing's syndrome.

buffalo hump
Gibbus A popular term for a mass of adipose tissue present at the lower cervical and upper thoracic vertebrae, characteristically seen in Cushing's disease/syndrome; a gibbus may also accumulate in the thoracolumbar regions of black South Africans with achondroplasia–possibly related to their practice of carrying infants on their backs, mucopolysaccharidoses, chronic osteomyelitis induced by coccidioidomycosis and M tuberculosis


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Initial efforts to define lipodystrophy were based on the assumption that the syndrome was related to the use of PIs, despite the fact that many symptoms-including half of the cases reported in the first paper on buffalo humps (5)--were seen in patients who had never taken PIs.
 
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