bryostatin(redirected from Bryostatins)
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bryostatinAny of a group of 20 different macrolide lactones isolated from a species of bryozoans (moss animals), a phylum of aquatic invertebrates (Bugula neritina), which upregulate protein kinase C (PKC) activity in the short term, and downregulate PKC with prolonged exposure. Bryostatin I inhibits cell growth and angiogenesis, drives cell differentiation and apoptosis and has immunomodulatory activity. While it showed promise as a memory enhancer and in cancer management, it failed as a monotherapy in phase-II clinical trials.