AKAP13

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AKAP13

A gene on chromosome 15q24-q25 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of cAMP-dependent protein kinase A (PKA), confining PKA to discrete locations within the cell based on different targeting motifs. Alternative splicing of AKAP13 results in at least 3 transcript variants that encode different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain with various functions. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, activating GTPase and resulting in signal transduction. The isoforms function as scaffolding proteins to co-ordinate a Rho-signalling pathway and function as PKA-anchoring proteins
References in periodicals archive ?
IPM will be able to apply the bench scale of this leach process as a routine assay procedure for most future BRX work, as well as specific check assaying on the original grid samples.
This will lead to the immediate processing of samples from IPM's exploration drill program completed in July and allow management to accelerate the development of BRX.
Ultimately, this metallurgical research will allow IPM and Behre Dolbear to conclusively define the grades of gold and platinum at BRX.
Note: "Depth of Sediments" indicates the drilling of BRX basin material until bedrock.
independent consultants to IPM, to supervise an Expanded recovery verification program through the initial bulk sampling of approximately 450 tons of BRX material.
The BRX, like any other reticle with some type of holdover bars, can be used to range as well as shoot at incline angles.
Over-The-Air Wireless (OTA), a leading developer of wireless entertainment technologies, today announced the adoption of Covault(TM) Corporation's BRX software platform to provide transaction-based billing for downloadable ringtones and other wireless entertainment.
You are about to bust an animal with your rifle whose bars are increasing incremental bars like the Swarovski BRX or the Zeiss RZ800 and he gives you a call of "2.
Auto Business News-6 May 2008-Leftlane News reveals details of 2010 Cadillac BRX crossover(C)2008 ENPublishing - http://www.
In the two BRX awards, Wolverhampton was named best group and Paul Woods was best chairman for his work at Bromsgrove.
BRX can add billing records to existing bills and allows carriers and subscribers to access their billing and usage details online.